ArticleCell cycle (Georgetown, Tex.)2016
New insights into the regulation by RUNX1 and GFI1(s) proteins of the endothelial to hematopoietic transition generating primordial hematopoietic cells.
Article in Cell cycle (Georgetown, Tex.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- LSD1/KDM1A and GFI1B repress endothelial fate and induce hematopoietic fate in induced pluripotent stem cell-derived hemogenic endothelium.Haematologica · 2024Article
- Exploring the Molecular and Developmental Dynamics of Endothelial Cell Differentiation.International journal of stem cells · 2024Review
- Endothelial Cell Differentiation and Hemogenic Specification.Cold Spring Harbor perspectives in medicine · 2022Review
- First blood: the endothelial origins of hematopoietic progenitors.Angiogenesis · 2021Review
- Human yolk sac-like haematopoiesis generatesDevelopment (Cambridge, England) · 2020Article
- Platelet CD34 expression in a patient with a partial deletion of transcription factor subunit CBFB.American journal of hematology · 2020Article
- Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate.Science advances · 2020Article
- Regulation of N6-Methyladenosine in the Differentiation of Cancer Stem Cells and Their Fate.Frontiers in cell and developmental biology · 2020Review
- In vivo generation of haematopoietic stem/progenitor cells from bone marrow-derived haemogenic endothelium.Nature cell biology · 2019Article
- GATA2 Is Dispensable for Specification of Hemogenic Endothelium but Promotes Endothelial-to-Hematopoietic Transition.Stem cell reports · 2018Article
- HDAC1 and HDAC2 Modulate TGF-β Signaling during Endothelial-to-Hematopoietic Transition.Stem cell reports · 2018Article
- Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation.Nature cell biology · 2018Article
- Primitive erythrocytes are generated from hemogenic endothelial cells.Scientific reports · 2017Article
- Transcription Factor GFI1B in Health and Disease.Frontiers in oncology · 2017Review
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
The first hematopoietic cells are generated very early in ontogeny to support the growth of the embryo and to provide the foundation to the adult hematopoietic system. There is a considerable therapeutic interest in understanding how these first blood cells are generated in order to try to reproduce this process in vitro. This would allow generating blood products, or hematopoietic cell populations from embryonic stem (ES) cells, induced pluripotent stem cells or through directed reprogramming. Recent studies have clearly established that the first hematopoietic cells originate from a hemogenic endothelium (HE) through an endothelial to hematopoietic transition (EHT). The molecular mechanisms underlining this transition remain largely unknown with the exception that the transcription factor RUNX1 is critical for this process. In this Extra Views report, we discuss our recent studies demonstrating that the transcriptional repressors GFI1 and GFI1B have a critical role in the EHT. We established that these RUNX1 transcriptional targets are actively implicated in the downregulation of the endothelial program and the loss of endothelial identity during the formation of the first blood cells. In addition, our results suggest that GFI1 expression provides an ideal novel marker to identify, isolate and study the HE cell population.
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