ArticleMedicine2016
Characterization of the Myocarditis during the worst outbreak of dengue infection in China.
Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- A systematic review of ultrasound to predict severe disease in patients with dengue and other viral infections associated with hemorrhagic fevers.PLoS neglected tropical diseases · 2026Pooled it
- Arrhythmias in Dengue: A Systematic Review and Meta-Analysis.Pathogens (Basel, Switzerland) · 2026Pooled it
- Pooled it
- Characteristics and associated factors of acute kidney injury among adult dengue patients: A retrospective single-center study.PloS one · 2019Trial
- ECG changes and their utility in adult Vietnamese patients with non-severe dengue.BMC infectious diseases · 2026Observational
- Review
- Dengue Myocarditis: A Retrospective Study From 2019 to 2023 in a Tertiary Care Hospital in Bangladesh.Cureus · 2025Article
- Dengue Cardiomyopathy Treatment Strategy Optimisation by Integrating Point of Care Ultrasound (POCUS) with VExUS.POCUS journal · 2024Article
- Review
- Dengue beyond fever-fatal dengue myocarditis and complete heart block: A case report and brief overview of cardiac manifestations of dengue fever.SAGE open medical case reports · 2023Article
- Dengue Myocarditis: A Case Report and Major Review.Global heart · 2023Review
- Dengue and COVID-19: two sides of the same coin.Journal of biomedical science · 2022Review
- Rescue therapy with intravenous immunoglobulin in severe refractory dengue: A pilot study.Medical journal, Armed Forces India · 2022Article
- Persistent viral infections and their role in heart disease.Frontiers in microbiology · 2022Review
- Prevalence and Outcomes of Myocarditis in Dengue-Infected Patients Admitted to a Tertiary Care Hospital of Low-Middle Income Country.Global heart · 2022Review
- Review
- Cardiac evaluation in adults with dengue virus infection by serial echocardiography.BMC infectious diseases · 2021Article
- Epidemiological Impact of Myocarditis.Journal of clinical medicine · 2021Review
- Myocarditis: an uncommon manifestation of dengue fever infection.BMJ case reports · 2021Article
- Myocarditis in admitted patients with dengue fever.Infection · 2020Observational
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myocarditis is a common complication of severe dengue infection. However, data about prevalence and characterization of myocarditis in dengue are still lacking. In 2014, the worst outbreak of dengue in the last two decades in China occurred. In this study, we described the clinical and laboratory diagnostic features of dengue with myocarditis. Totally, 1782 diagnosed dengue patients were admitted from August to October, 2014, all of whom were subjected to electrocardiogram, ultrasound cardiogram, and cardiac enzyme test. About 201 cases of dengue patients were diagnosed with myocarditis and the prevalence of myocarditis in hospitalized dengue was 11.28%. The prevalence of myocarditis in nonsevere dengue with warning signs and severe dengue [NSD(WS+)/SD] and nonsevere dengue without warning signs [NSD(WS-)] was 46.66% and 9.72%, respectively. The NSD(WS+)/SD patients with myocarditis presented with higher incidence of cardiac symptoms, supraventricular tachycardia (14.29% vs. 0%, P < 0.001), atrial fibrillation (25.71% vs. 10.24%, P = 0.019) and heart failure compared with NSD (WS-) patients with myocarditis. About 150 cases of dengue patients without myocarditis in the same period of time in department of Cardiology were recruited as control group. The proportion of NSD(WS+)/SD in dengue patients with and without myocarditis was 17.41% and 2.53%, respectively. Dengue patients with myocarditis experienced longer hospital stay than those without myocarditis (7.17 ± 4.64 vs. 5.98 ± 2.69, P = 0.008). There was no difference between patients with and without myocarditis in the proportion of symptoms, auxiliary methods abnormality, arrhythmia, and heart failure on the discharge day. Our study demonstrates the prevalence of myocarditis in worst outbreak of dengue in China was 11.28% and the incidence of myocarditis increased with the severity of dengue. The NSD(WS+)/SD patients with myocarditis presented with higher incidence of cardiac complication compared with NSD (WS-) patients with myocarditis. The prognosis of dengue patients with and without myocarditis had no significant difference even if myocarditis patients experienced longer hospital stay.
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