Trial reportAnnals of the American Thoracic Society2016
Effect of Continuous Positive Airway Pressure on Airway Reactivity in Asthma. A Randomized, Sham-controlled Clinical Trial.
Trial report in Annals of the American Thoracic Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01629823 (Effect of Positive Airway Pressure on Reducing Airway Reactivity in Patients With Asthma), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Positive Airway Pressure on Reducing Airway Reactivity in Patients With Asthma
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Non-invasive positive pressure ventilation for acute asthma in children.The Cochrane database of systematic reviews · 2024Pooled it
- A randomized trial of continuous positive airway pressure for the asthma of obesity.Respiratory research · 2025Trial
- Continuous positive airway pressure acutely increases exercise duration in children with severe therapy-resistant asthma: a randomized crossover trial.World journal of pediatrics : WJP · 2021Trial
- Nocturnal bilevel positive airway pressure for the treatment of asthma.Respiratory physiology & neurobiology · 2020Trial
- Performance of the Asthma Impact on Quality of Life Scale (A-IQOLS) in diverse asthma research populations and demographic subgroups.The Journal of allergy and clinical immunology · 2019Trial
- Reproducibility of airway luminal size in asthma measured by HRCT.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Effect Heterogeneity of CPAP on MACE by Nocturnal Hypoxia Burden in Older Adults OSAS: A Propensity Score Matching Study.Clinical interventions in aging · 2026Article
- Asthma and Obstructive Sleep Apnea Overlap: What Has the Evidence Taught Us?American journal of respiratory and critical care medicine · 2020Review
- Perioperative Implications of Vaping.Journal of medical cases · 2020Article
- The Effects of Obesity in Asthma.Current allergy and asthma reports · 2019Review
- Older age and obesity are associated with increased airway closure in response to methacholine in patients with asthma.Respirology (Carlton, Vic.) · 2019Article
- Effect of CPAP on airway reactivity and airway inflammation in children with moderate-severe asthma.Respirology (Carlton, Vic.) · 2019Article
- Current opinions for the management of asthma associated with ear, nose and throat comorbidities.European respiratory review : an official journal of the European Respiratory Society · 2018Review
- Non-invasive positive pressure ventilation for acute asthma in children.The Cochrane database of systematic reviews · 2016Review
- Management of Severe Asthma before Referral to the Severe Asthma Specialist.The journal of allergy and clinical immunology. In practiceReview
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
rationaleStudies have demonstrated that application of stress suppresses airway smooth muscle contractility. In animal models of asthma, continuous positive airway pressure (CPAP) reduced airway reactivity. Short-term studies of CPAP in patients with asthma showed reductions in airway reactivity.
objectivesTo evaluate whether nocturnal CPAP decreased the provocative concentration of methacholine to reduce FEV
methodsOne hundred ninety-four individuals with asthma were randomized (1:1:1) to use CPAP with warmed, filtered, humidified air at night at pressures either less than 1 cm H MEASUREMENTS AND MAIN
resultsAdherence to CPAP was low in all groups. Regardless, all groups had a significant improvement in PC
conclusionsAdherence to nocturnal CPAP was low. There was no evidence to support positive pressure as being effective for reducing airway reactivity in people with well-controlled asthma. Regardless, airway reactivity was improved in all groups, which may represent an effect of participating in a study and/or an effect of warm, humid, filtered air on airway reactivity. Clinical trial registered with www.clinicaltrials.gov (NCT01629823).
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.