Evidence map›Paper›PMID 27398989›Full record

ArticleThe American journal of drug and alcohol abuse2017

Marijuana use and viral suppression in persons receiving medical care for HIV-infection.

Chukwuemeka N Okafor, Zhi Zhou, Larry E Burrell, Natalie E Kelso, Nicole E Whitehead, Jeffery S Harman, Christa L Cook, Robert L Cook

Abstract read
In one paragraph

Article in The American journal of drug and alcohol abuse, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chukwuemeka N Okafora Department of Epidemiology , College of Public Health and Health Professions, College of Medicine, University of Florida , Gainesville , FL , USA.
Zhi Zhoua Department of Epidemiology , College of Public Health and Health Professions, College of Medicine, University of Florida , Gainesville , FL , USA.
Larry E Burrellb Department of Clinical and Health Psychology , College of Public Health and Health Professions, University of Florida , Gainesville , FL , USA.
Natalie E Kelsoa Department of Epidemiology , College of Public Health and Health Professions, College of Medicine, University of Florida , Gainesville , FL , USA.
Nicole E Whiteheadb Department of Clinical and Health Psychology , College of Public Health and Health Professions, University of Florida , Gainesville , FL , USA.
Jeffery S Harmanc Department of Behavioral Sciences & Social Medicine , College of Medicine, Florida State University , Tallahassee , FL , USA.
Christa L Cookd Department of Family, Community, and Health System Science , College of Nursing, University of Florida , Gainesville , FL , USA.
Robert L Cooka Department of Epidemiology , College of Public Health and Health Professions, College of Medicine, University of Florida , Gainesville , FL , USA.

Funding

Southern HIV and Alcohol Research Consortium Administrative and Research Support CoreU24AA022002 · NIAAA · UNIVERSITY OF FLORIDA · PI COOK, ROBERT L · 2012 to 2022
$5.5M
Feasibility of SBIRT for Underserved HIV+ Adults 50+ in Primary Care SettingsK23DA039769 · NIDA · UNIVERSITY OF FLORIDA · PI ENNIS, NICOLE · 2016 to 2020
$769k
Alcohol Consumption Patterns on Cardiovascular Health in Persons Living with HIVF31AA024064 · NIAAA · UNIVERSITY OF FLORIDA · PI CHICHETTO, NATALIE E · 2015 to 2016
$69k
The impact of long-term marijuana use on the neurocognitive functioning of individuals living with HIVF31DA039810 · NIDA · UNIVERSITY OF FLORIDA · PI OKAFOR, CHUKWUEMEKA NKEMAKONAM · 2015 to 2016
$60k
NIAAA NIH HHS F31 AA024064NIAAA NIH HHS U24 AA022002NIDA NIH HHS F31 DA039810NIDA NIH HHS K23 DA039769
6 · The paper itself

Abstract

backgroundMarijuana use is common among persons living with HIV (PLWH), but studies on its effect on HIV clinical outcomes are limited.

objectivesWe determined the association between marijuana use and HIV viral suppression among PLWH.

methodsData came from five repeated cross-sections (2009-2013) of the Florida Medical Monitoring Project, a population-based sample of PLWH in Florida. Data were obtained via interview and medical record abstraction (MRA). Weighted logistic regression models were used to determine the association between marijuana use (past 12 months) and durable viral suppression (HIV-1 RNA value of ≤ 200 copies/milliliter in all measurements within the past 12 months).

resultsOf the 1,902 PLWH receiving antiretroviral therapy, completed an interview, and had a linked MRA, 20% reported marijuana use (13% less than daily and 7% daily use) and 73% achieved durable viral suppression. In multivariable analysis, marijuana use was not significantly associated with durable viral suppression in daily [Adjusted Odds Ratio (AOR): 0.87, 95% confidence interval (CI): 0.58, 1.33] or in less than daily [AOR: 0.83, 95% CI: 0.51, 1.37] users as compared to non-users when adjusting for sociodemographic factors, time since HIV diagnosis, depressive symptoms, alcohol, cigarette and other substance use.

conclusionIn this sample of PLWH receiving medical care in Florida, there was no statistically significant association between marijuana use and viral suppression. However, as the limits of the confidence intervals include effects that may be considered to be clinically important, there is a need for additional evidence from other samples and settings that include more marijuana users.

Indexed as

AdolescentAdultAnti-Retroviral AgentsDatabases, FactualFemaleHIV InfectionsHumansMaleMarijuana SmokingMiddle AgedViral LoadYoung AdultAnti-Retroviral AgentsHIVmarijuanapersons living with HIV (PLWH)viral suppression

Identifiers

PMID27398989
PMCPMC5226929

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.