ArticleThe journal of trauma and acute care surgery2016
Characterization of erythropoietin and hepcidin in the regulation of persistent injury-associated anemia.
Article in The journal of trauma and acute care surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- LncRNA and mRNA expression characteristic and bioinformatic analysis in anemic diabetic foot ulcers.Frontiers in genetics · 2025Article
- Predictive factors of medium-giant coronary artery aneurysms in Kawasaki disease.Pediatric research · 2024Article
- To what extent classic socio-economic determinants explain trends of anaemia in tribal and non-tribal women of reproductive age in India? Findings from four National Family Heath Surveys (1998-2021).BMC public health · 2023Article
- Anemia Recovery after Trauma: A Longitudinal Study.Surgical infections · 2023Article
- Mechanisms of improved erythroid progenitor growth with removal of chronic stress after trauma.Surgery · 2022Article
- Week-One Anaemia was Associated with Increased One-Year Mortality in Critically Ill Surgical Patients.International journal of clinical practice · 2022Article
- Prolonged Chronic Stress and Persistent Iron Dysregulation Prevent Anemia Recovery Following Trauma.The Journal of surgical research · 2021Article
- Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018.Nature medicine · 2021Article
- Physiological and Clinical Impact of Repeated Inhaled Oxygen Variation on Erythropoietin Levels in Patients After Surgery.Frontiers in physiology · 2021Article
- Vitamin D status is associated with hepcidin and hemoglobin concentrations in patients with severe traumatic injury.The journal of trauma and acute care surgery · 2020Observational
- The effects of selective beta-adrenergic blockade on bone marrow dysfunction following severe trauma and chronic stress.American journal of surgery · 2020Article
- Impact of Injury Severity on the Inflammatory State and Severe Anemia.The Journal of surgical research · 2020Observational
- Systemic Regulation of Bone Marrow Stromal Cytokines After Severe Trauma.The Journal of surgical research · 2019Article
- Chronic stress induces persistent low-grade inflammation.American journal of surgery · 2019Article
- The Postinjury Inflammatory State and the Bone Marrow Response to Anemia.American journal of respiratory and critical care medicine · 2018Observational
- Dysregulated myelopoiesis and hematopoietic function following acute physiologic insult.Current opinion in hematology · 2018Review
- Severe trauma and chronic stress activates extramedullary erythropoiesis.The journal of trauma and acute care surgery · 2017Article
- Daily propranolol administration reduces persistent injury-associated anemia after severe trauma and chronic stress.The journal of trauma and acute care surgery · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe cause of persistent injury-associated anemia is multifactorial and includes acute blood loss, an altered erythropoietin (EPO) response, dysregulation of iron homeostasis, and impaired erythropoiesis in the setting of chronic inflammation/stress. Hepcidin plays a key role in iron homeostasis and is regulated by anemia and inflammation. Erythropoietin is a main regulator of erythropoiesis induced by hypoxia. A unique rodent model of combined lung injury (LC)/hemorrhagic shock (HS) (LCHS)/chronic restraint stress (CS) was used to produce persistent injury-associated anemia to further investigate the roles of EPO, hepcidin, iron, ferritin, and the expression of EPO receptors (EPOr).
methodsMale Sprague-Dawley rats were randomly assigned into one of the four groups of rodent models: naive, CS alone, combined LCHS, or LCHS/CS. Plasma was used to evaluate levels of EPO, hepcidin, iron, and ferritin. RNA was isolated from bone marrow and lung tissue to evaluate expression of EPOr. Comparisons between models were performed by t tests followed by one-way analysis of variance.
resultsAfter 7 days, only LCHS/CS was associated with persistent anemia despite significant elevation of plasma EPO. Combined LCHS and LCHS/CS led to a persistent decrease in EPOr expression in bone marrow on Day 7. The LCHS/CS significantly decreased plasma hepcidin levels by 75% on Day 1 and 84% on Day 7 compared to LCHS alone. Hepcidin plasma levels are inversely proportional to EPO plasma levels (Pearson R = -0.362, p < 0.05).
conclusionTissue injury, hemorrhagic shock, and stress stimulate and maintain high levels of plasma EPO while hepcidin levels are decreased. In addition, bone marrow EPOr and plasma iron availability are significantly reduced following LCHS/CS. The combined deficit of reduced iron availability and reduced bone marrow EPOr expression may play a key role in the ineffective EPO response associated with persistent injury-associated anemia.
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