ArticleHistopathology2016
Histological features associated with diagnostic agreement in atypical ductal hyperplasia of the breast: illustrative cases from the B-Path study.
Article in Histopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- "Borderline" epithelial lesions of the breast: what have we learned in the past three decades?Pathologica · 2021Review
- Deep Feature Representations for Variable-Sized Regions of Interest in Breast Histopathology.IEEE journal of biomedical and health informatics · 2021Article
- Inter-observer reproducibility of classical lobular neoplasia (B3 lesions) in preoperative breast biopsies: a study of the Swiss Working Group of breast and gynecopathologists.Journal of cancer research and clinical oncology · 2020Observational
- Detection and classification of cancer in whole slide breast histopathology images using deep convolutional networks.Pattern recognition · 2018Article
- Multi-Instance Multi-Label Learning for Multi-Class Classification of Whole Slide Breast Histopathology Images.IEEE transactions on medical imaging · 2018Article
- The diagnostic challenge of low-grade ductal carcinoma in situ.European journal of cancer (Oxford, England : 1990) · 2017Article
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Authors and funding
6 authors.
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Abstract
aimsThis study examined the case-specific characteristics associated with interobserver diagnostic agreement in atypical ductal hyperplasia (ADH) of the breast. METHODS AND
resultsSeventy-two test set cases with a consensus diagnosis of ADH from the B-Path study were evaluated. Cases were scored for 17 histological features, which were then correlated with the participant agreement with the consensus ADH diagnosis. Participating pathologists' perceptions of case difficulty, borderline features or whether they would obtain a second opinion were also examined for associations with agreement. Of the 2070 participant interpretations of the 72 consensus ADH cases, 48% were scored by participants as difficult and 45% as borderline between two diagnoses; the presence of both of these features was significantly associated with increased agreement (P < 0.001). A second opinion would have been obtained in 80% of interpretations, and this was associated with increased agreement (P < 0.001). Diagnostic agreement ranged from 10% to 89% on a case-by-case basis. Cases with papillary lesions, cribriform architecture and obvious cytological monotony were associated with higher agreement. Lower agreement rates were associated with solid or micropapillary architecture, borderline cytological monotony, or cases without a diagnostic area that was obvious on low power.
conclusionsThe results of this study suggest that pathologists frequently recognize the challenge of ADH cases, with some cases being more prone to diagnostic variability. In addition, there are specific histological features associated with diagnostic agreement on ADH cases. Multiple example images from cases in this test set are provided to serve as educational illustrations of these challenges.
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