Evidence map›Paper›PMID 27398409›Full record

ArticleJCI insight2016

Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases.

Gang Liu, Marion A Cooley, Andrew G Jarnicki, Alan C-Y Hsu, Prema M Nair, Tatt Jhong Haw, Michael Fricker, Shaan L Gellatly, Richard Y Kim, Mark D Inman and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it, 145 citations in OpenAlex.

  1. A Review of CXCL1 in Cardiac Fibrosis.Frontiers in cardiovascular medicine · 2021
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. WNT3a induces external anal sphincter fibrosis and dysfunction in rabbits.American journal of physiology. Gastrointestinal and liver physiology · 2026
    Article
  7. Article
  8. Review
  9. Review
  10. Serum response factor is essential for endometrial function and prevention of inflammatory fibrosis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Fibulin-7 and its bioactive fragments: emerging immunomodulatory roles in disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  16. Article
  17. Vitronectin regulates lung tissue remodeling and emphysema in chronic obstructive pulmonary disease.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  18. Article
  19. Article
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 4 countries.

Gang LiuPriority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Marion A CooleyDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina, USA.
Andrew G JarnickiPriority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Alan C-Y HsuPriority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Prema M NairPriority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Tatt Jhong HawPriority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Michael FrickerPriority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Shaan L GellatlyPriority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Richard Y KimPriority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Mark D InmanDivision of Respirology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Gavin TjinWoolcock Institute of Medical Research, Discipline of Pharmacology, The University of Sydney, Sydney, New South Wales, Australia.
Peter A B WarkPriority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia; Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia.
Marjorie M WalkerPriority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Jay C HorvatPriority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Brian G OliverWoolcock Institute of Medical Research, Discipline of Pharmacology, The University of Sydney, Sydney, New South Wales, Australia; School of Life Sciences, The University of Technology, Sydney, New South Wales, Australia.
W Scott ArgravesDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina, USA.
Darryl A KnightPriority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia; Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, British Columbia, Canada.
Janette K BurgessWoolcock Institute of Medical Research, Discipline of Pharmacology, The University of Sydney, Sydney, New South Wales, Australia; Discipline of Pharmacology, Sydney Medical School, The University of Sydney, New South Wales, Australia; Department of Pathology and Medical Biology, University of Groningen, University Medical Center, Groningen, Netherlands.
Philip M HansbroPriority Research for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia.
Medical University of South Carolina · USJohn Hunter Hospital · AUMcMaster University · CAUniversity Medical Center Groningen · NLUniversity of British Columbia · CA

Funding

South Carolina IDeA Networks of Biomedical Research (SC INBRE V)P20GM103499 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI EDIE C GOLDSMITH · 2012 to 2026
$61.0M
UBIQUITIN CARBOXYL TERMINAL HYDROLASE L1 (UCH-L1) AND VASCULAR LESION FORMATIONP20RR016434 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MARKWALD, ROGER R · 2001 to 2011
$24.8M
Fibulin-1 Regulation of the DiGeorge Syndrome Pathogenesis PathwayR01HL095067 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ARGRAVES, WILLIAM SCOTT · 2009 to 2012
$1.5M
Defining the Role of Fibulin-1 in Bone Formation and Bone RepairR03DE025309 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI COOLEY, MARION A. · 2016 to 2017
$223k
NCRR NIH HHS P20 RR016434NHLBI NIH HHS R01 HL095067NIDCR NIH HHS R03 DE025309NIGMS NIH HHS P20 GM103499
6 · The paper itself

Abstract

Airway and/or lung remodeling, involving exaggerated extracellular matrix (ECM) protein deposition, is a critical feature common to pulmonary diseases including chronic obstructive pulmonary disease (COPD), asthma, and idiopathic pulmonary fibrosis (IPF). Fibulin-1 (Fbln1), an important ECM protein involved in matrix organization, may be involved in the pathogenesis of these diseases. We found that Fbln1 was increased in COPD patients and in cigarette smoke-induced (CS-induced) experimental COPD in mice. Genetic or therapeutic inhibition of

Identifiers

PMID27398409
PMCPMC4936823
OpenAlexW2439973029

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.