ArticleJCI insight2016
A wearable artificial kidney for patients with end-stage renal disease.
Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
First 24 Hour Human Trial of the Wearable Artificial Kidney
The Effect of Sock Developed Wıth Wearable Technology for Patıents Undergoıng Transurethral Resectıon Surgery on the Development of Hypothermıa and Venous Thromboembolısm
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 163 citations in OpenAlex.
- Wearable Health Devices in Health Care: Narrative Systematic Review.JMIR mHealth and uHealth · 2020Pooled it
- Research Progress and Critical Challenges of Bioartificial Kidneys in Renal Replacement Therapy for End-Stage Renal Disease.Biomolecules · 2026Review
- Modelling and Experimental Study of Low Flow Rate Miniaturized Electrodialysis for Artificial Kidney Applications.Journal of applied physics · 2026Article
- Ten tips to preserve and reuse water in nephrology.Clinical kidney journal · 2026Review
- Vascular Access 4.0 for Hemodialysis: Toward a Needle-Free, Smart, Closed, and Connected System.Journal of clinical medicine · 2026Article
- Challenges and outcomes in pediatric and adult kidney transplantation.Frontiers in pediatrics · 2026Review
- Molecular dynamics study of urea adsorption on nitrogen and phosphorus doped carbon nanotubes for artificial kidney devices.Scientific reports · 2025Article
- Scalable ion concentration polarization dialyzer for peritoneal dialysate regeneration.Journal of nanobiotechnology · 2025Article
- From Home to Wearable Hemodialysis: Barriers, Progress, and Opportunities.Clinical journal of the American Society of Nephrology : CJASN · 2024Review
- Thermal Vapor Deposition of a Hydrophobic and Gas-Permeable Membrane on Zirconium Phosphate Cation Exchanger: An Oral Sorbent for the Urea Removal of Kidney Failure.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Artificial kidney: Challenges and opportunities.World journal of transplantation · 2024Review
- Advances in Human-Centered Care to Address Contemporary Unmet Needs in Chronic Dialysis.International journal of nephrology and renovascular disease · 2024Review
- Renal Embolization-Induced Uremic Swine Model for Assessment of Next-Generation Implantable Hemodialyzers.Toxins · 2023Article
- Portable, wearable and implantable artificial kidney systems: needs, opportunities and challenges.Nature reviews. Nephrology · 2023Review
- A Perfluorocarbon-Coated ZrP Cation Exchanger with Excellent Ammonium Selectivity and Chemical Stability: An Oral Sorbent for End-Stage Kidney Disease (ESKD).Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Advances in Enhancing Hemocompatibility of Hemodialysis Hollow-Fiber Membranes.Advanced fiber materials · 2023Review
- Novel strategies in nephrology: what to expect from the future?Clinical kidney journal · 2023Review
- Wearables in Nephrology: Fanciful Gadgetry or Prêt-à-Porter?Sensors (Basel, Switzerland) · 2023Review
- Advances in hemodialysis therapy.Faculty reviews · 2023Review
- Hierarchically structural layered double oxides with stretchable nanopores for highly effective removal of protein-bound uremic toxins.Separation and purification technology · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundStationary hemodialysis machines hinder mobility and limit activities of daily life during dialysis treatments. New hemodialysis technologies are needed to improve patient autonomy and enhance quality of life.
methodsWe conducted a FDA-approved human trial of a wearable artificial kidney, a miniaturized, wearable hemodialysis machine, based on dialysate-regenerating sorbent technology. We aimed to determine the efficacy of the wearable artificial kidney in achieving solute, electrolyte, and volume homeostasis in up to 10 subjects over 24 hours.
resultsDuring the study, all subjects remained hemodynamically stable, and there were no serious adverse events. Serum electrolytes and hemoglobin remained stable over the treatment period for all subjects. Fluid removal was consistent with prescribed ultrafiltration rates. Mean blood flow was 42 ± 24 ml/min, and mean dialysate flow was 43 ± 20 ml/min. Mean urea, creatinine, and phosphorus clearances over 24 hours were 17 ± 10, 16 ± 8, and 15 ± 9 ml/min, respectively. Mean β
conclusionTreatment with the wearable artificial kidney was well tolerated and resulted in effective uremic solute clearance and maintenance of electrolyte and fluid homeostasis. These results serve as proof of concept that, after redesign to overcome observed technical problems, a wearable artificial kidney can be developed as a viable novel alternative dialysis technology.
trial registrationClinicalTrials.gov NCT02280005.
fundingThe Wearable Artificial Kidney Foundation and Blood Purification Technologies Inc.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.