ArticleFEBS open bio2016
Age-dependent transcriptional and epigenomic responses to light exposure in the honey bee brain.
Article in FEBS open bio, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Division of labour during honeybee colony defence: poetic and scientific views.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- The role of learning-walk related multisensory experience in rewiring visual circuits in the desert ant brain.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Review
- Novel structure in the nuclei of honey bee brain neurons revealed by immunostaining.Scientific reports · 2021Article
- Plasticity and modulation of olfactory circuits in insects.Cell and tissue research · 2021Review
- Epigenetic Molecular Mechanisms in Insects.Neotropical entomology · 2020Review
- Exploring DNA Methylation Diversity in the Honey Bee Brain by Ultra-Deep Amplicon Sequencing.Epigenomes · 2020Article
- Review
- Immediate early genes in social insects: a tool to identify brain regions involved in complex behaviors and molecular processes underlying neuroplasticity.Cellular and molecular life sciences : CMLS · 2019Review
- Sequence and structural properties of circular RNAs in the brain of nurse and forager honeybees (Apis mellifera).BMC genomics · 2019Article
- Characterization of a Dopamine Transporter and Its Splice Variant Reveals Novel Features of Dopaminergic Regulation in the Honey Bee.Frontiers in physiology · 2019Article
- Tensor decomposition-based and principal-component-analysis-based unsupervised feature extraction applied to the gene expression and methylation profiles in the brains of social insects with multiple castes.BMC bioinformatics · 2018Article
- Opsin expression patterns coincide with photoreceptor development during pupal development in the honey bee, Apis mellifera.BMC developmental biology · 2018Article
- Detecting rare asymmetrically methylated cytosines and decoding methylation patterns in the honeybee genome.Royal Society open science · 2017Article
- Article
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Authors and funding
4 authors.
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Abstract
Light is a powerful environmental stimulus of special importance in social honey bees that undergo a behavioral transition from in-hive to outdoor foraging duties. Our previous work has shown that light exposure induces structural neuronal plasticity in the mushroom bodies (MBs), a brain center implicated in processing inputs from sensory modalities. Here, we extended these analyses to the molecular level to unravel light-induced transcriptomic and epigenomic changes in the honey bee brain. We have compared gene expression in brain compartments of 1- and 7-day-old light-exposed honey bees with age-matched dark-kept individuals. We have found a number of differentially expressed genes (DEGs), both novel and conserved, including several genes with reported roles in neuronal plasticity. Most of the DEGs show age-related changes in the amplitude of light-induced expression and are likely to be both developmentally and environmentally regulated. Some of the DEGs are either known to be methylated or are implicated in epigenetic processes suggesting that responses to light exposure are at least partly regulated at the epigenome level. Consistent with this idea light alters the DNA methylation pattern of bgm, one of the DEGs affected by light exposure, and the expression of microRNA miR-932. This confirms the usefulness of our approach to identify candidate genes for neuronal plasticity and provides evidence for the role of epigenetic processes in driving the molecular responses to visual stimulation.
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