ArticleDrugs - real world outcomes2016
Persistence of Antipsychotic Treatment in Elderly Dementia Patients: A Retrospective, Population-Based Cohort Study.
Article in Drugs - real world outcomes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bipolar Disorder and Manic-Like Symptoms in Alzheimer's, Vascular and Frontotemporal Dementia: A Systematic Review.Current neuropharmacology · 2023Pooled it
- Antipsychotic Use in Older Adults with Dementia: Community and Nursing Facility Trends in Texas, 2015-2020.Journal of the American Medical Directors Association · 2025Article
- Antipsychotic use among older patients with dementia receiving home health care services: Prevalence, predictors, and outcomes.Journal of the American Geriatrics Society · 2023Article
- Assessment of the Risk of Antipsychotics in Patients with Dementia in Actual Clinical Practice in Primary Health Care.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Discontinuation of antipsychotics treatment for elderly patients within a specialized behavioural unit: a retrospective review.International journal of clinical pharmacy · 2021Article
- Greater than the Sum: Applying Daily-Dose Equivalents to Antipsychotic Prescription Claims to Study Real-World Effects.Frontiers in pharmacology · 2021Article
- Antipsychotic initiation among adults with intellectual and developmental disabilities in Ontario: a population-based cohort study.BMJ open · 2019Article
- Interprovincial Variation of Psychotropic Prescriptions Dispensed to Older Canadian Adults.Canadian geriatrics journal : CGJ · 2018Article
- Detecting and Managing Neuropsychiatric Symptoms in Dementia.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Article
- [Treatment with psychotropic agents in patients with dementia and delirium : Gap between guideline recommendations and treatment practice].Zeitschrift fur Gerontologie und Geriatrie · 2017Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntipsychotics are commonly used to manage behavioral and psychological symptoms of dementia. Concerns over their safety and efficacy in this role have resulted in antipsychotics typically being recommended for short-term usage only when used among dementia patients. However, there is little work examining the duration of antipsychotic treatment in the elderly dementia patient population.
objectiveTo determine the persistence of use of antipsychotics in elderly dementia patients and the role of dose on therapy duration.
methodsA retrospective, population-based cohort study using administrative data, including dispensing records from a provincial public drug program, from Ontario, Canada between 2009 and 2012. Elderly dementia patients newly initiated onto antipsychotics were followed until drug discontinuation, death, 2-year follow-up, or end of study. Competing risk analysis was performed to determine time to discontinuation, stratified by categories of initial dose.
resultsAfter 2 years 49.1 % of the cohort (
conclusionApproximately half of elderly dementia patients treated with antipsychotics discontinue within 2 years, with those on higher doses more likely to discontinue. However, the number of patients remaining on therapy represents a serious public health concern.
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Registered trials
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