Evidence map›Paper›PMID 27398286›Full record

ArticleCurrent developmental disorders reports2016

The Brain-Gut-Microbiome Axis: What Role Does It Play in Autism Spectrum Disorder?

Ruth Ann Luna, Tor C Savidge, Kent C Williams

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current developmental disorders reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03401736 (A Study on the Relationship Between Biodiversity of Intestinal Microbiota in Patients and Different Sedative-hypnotics Undergoing Mechanical Ventilation), which is not on this map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
12.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03401736 nawithdrawnnot on this mapstarted 2018, after this paper: background citation

A Study on the Relationship Between Biodiversity of Intestinal Microbiota in Patients and Different Sedative-hypnotics Undergoing Mechanical Ventilation

TypeinterventionalSponsorShanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong UniversityRan2018 to 2020Enrolled0ConditionsIntestinal Microbiota, Mechanical VentilationArmsMechanical Ventilation, Midazolam, Dexmedetomidine
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ruth Ann LunaDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA; Texas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, Texas, USA.
Tor C SavidgeDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA; Texas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, Texas, USA.
Kent C WilliamsDepartment of Pediatric Gastroenterology, Nationwide Children's Hospital, Columbus, Ohio, USA.
Baylor College of Medicine · USNationwide Children's Hospital · US

Funding

Allosteric therapy of the Clostridium difficile toxinsR01AI100914 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SAVIDGE, TOR C. · 2012 to 2016
$1.9M
NIAID NIH HHS R01 AI100914
6 · The paper itself

Abstract

The brain-gut-microbiome axis refers to the interactions between the central nervous system, gastrointestinal system, and microorganisms that live in the gastrointestinal tract. Exploring these interactions provides a rationale for why gastrointestinal disorders commonly occur in children with Autism Spectrum Disorders (ASD). Signs of altered brain-gut interactions that are closely associated with functional GI disorders (FGIDs) commonly occur in children with ASD. Studies of microbiome in ASD suggest that changes in the gut microbiome may be associated with ASD and with GI disorders in children with ASD. Further studies into the brain-gut-microbiome axis could lead to new techniques for identifying GI disorders in children with ASD and novel therapies for treating ASD behaviors.

Indexed as

ASD behaviorsAutism Spectrum Disorders, ASDbrain-gut axiscentral nervous systemdevelopmental disordersfunctional GI disordersGI disordersgut microbiomereview

Identifiers

PMID27398286
PMCPMC4933016
OpenAlexW2291641916

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.