ArticleAmerican journal of translational research2016
Defects in dermal Vγ4 γ δ T cells result in delayed wound healing in diabetic mice.
Article in American journal of translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 19 citations in OpenAlex.
- Immune cells in diabetic wound repair: the key to better wound management.Frontiers of medicine · 2025Review
- Impact of obesity on the CCR6-CCL20 axis in epidermal γδ T cells and IL-17A production in murine wound healing and psoriasis.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- γδ T cells in diabetes mellitus: dual roles and therapeutic implications.Frontiers in immunology · 2025Review
- Spatiotemporal orchestration of macrophage activation trajectories by Vγ4 T cells during skin wound healing.iScience · 2024Article
- Impact of Obesity on the CCR6-CCL20 Axis in Epidermal γδ T Cells and IL-17A Production in Murine Wound Healing and Psoriasis.bioRxiv : the preprint server for biology · 2024Article
- Immunomodulatory Nanosystems: Advanced Delivery Tools for Treating Chronic Wounds.Research (Washington, D.C.) · 2023Review
- The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity.Military Medical Research · 2022Review
- [Role and mechanism of Vγ4 T cells in impaired wound healing of rapamycin-induced full-thickness skin defects in mice].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- The Role of T Lymphocytes in Cutaneous Scarring.Advances in wound care · 2022Review
- Maintenance of Barrier Tissue Integrity by Unconventional Lymphocytes.Frontiers in immunology · 2021Review
- Skin Resident γδ T Cell Function and Regulation in Wound Repair.International journal of molecular sciences · 2020Review
- Immune Cell Therapies to Improve Regeneration and Revascularization of Non-Healing Wounds.International journal of molecular sciences · 2020Review
- CCR6The Journal of investigative dermatology · 2019Article
- Vγ4 T Cells Inhibit the Pro-healing Functions of Dendritic Epidermal T Cells to Delay Skin Wound Closure Through IL-17A.Frontiers in immunology · 2018Article
- Functions of Vγ4 T Cells and Dendritic Epidermal T Cells on Skin Wound Healing.Frontiers in immunology · 2018Review
- Dermal VγAmerican journal of translational research · 2017Article
- IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice.Frontiers in immunology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The skin serves as a physical and chemical barrier to provide an initial line of defense against environmental threats; however, this function is impaired in diabetes. Vγ4 γ δ T cells in the dermis are an important part of the resident cutaneous immunosurveillance program, but these cells have yet to be explored in the context of diabetes. In this study, we observed that the impaired maintenance of dermal Vγ4 γ δ T cells is caused by reduced production of IL-7 in the skin of diabetic mice, which was closely associated with weakened activation of the mTOR pathway in the epidermis of diabetic mice. Weakened CCL20/CCR6 chemokine signaling resulted in the impaired recruitment of dermal Vγ4 γ δ T cells following wounding in diabetic mice. Meanwhile, reduced levels of IL-23 and IL-1β in the dermis around the wounds of diabetic mice resulted in the impaired production of IL-17 by dermal Vγ4 γ δ T cells. Therefore, diminished dermal Vγ4 γ δ T cells and impaired IL-17 production by these cells were important factors in the markedly reduced IL-17 levels in the skin around the wounds of diabetic mice. Because reduced IL-17 levels at the wound edge have been closely associated with delayed wound closure in diabetic mice, defects in dermal Vγ4 γ δ T cells may be an important mechanism underlying delayed wound healing in diabetic mice.
Indexed as
Identifiers
27398150PMC4931161W2502830972What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.