How we do: optimizing bone marrow biopsy logistics for sign-out within 2 days.

I de Laak-de Vries, A G Siebers, L Burgers, C Diepenbroek, M Link, P Groenen, J H J M van Krieken, K M Hebeda

Abstract read

In one paragraph

Article in Journal of hematopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Next-generation sequencing-based IG clonality analysis to discriminate reactive infiltrates from minimal lymphoma involvement in paired lymphoma and bone marrow biopsies; a EuroClonality-NGS Working Group study.Histopathology · 2026
Article
Age-Related Alterations in SIBLING Proteins and Dentin Micro-Architecture: Morphological and Molecular Associations.Life (Basel, Switzerland) · 2025
Article
Practical diagnostic approach to assess myeloid and precursor cell neoplasms on trephine bone marrow biopsies: reflection of middle European reality.Journal of hematopathology · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

I de Laak-de VriesDepartment of Pathology 824, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

A G SiebersDepartment of Pathology 824, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.ORCID 0000-0002-6085-0678

L BurgersDepartment of Pathology 824, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

C DiepenbroekDepartment of Pathology 824, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

M LinkDepartment of Pathology 824, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

P GroenenDepartment of Pathology 824, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

J H J M van KriekenDepartment of Pathology 824, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

K M HebedaDepartment of Pathology 824, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the introduction of fast diagnostic tracks in many areas of oncology, the traditional processing of bone marrow biopsies (BMB), requiring either resin embedding or lengthy fixation and decalcification, is due to an upgrade. Thanks to a growing number of new commercially available tissue processors, microwave-enhanced processing is becoming a standard tool in the pathology laboratory, allowing rapid fixation and decalcification of BMB with preserved morphology and antigens. In this short report, we describe the use of a commercially available EDTA-based decalcification fluid (USEDECALC, Medite, Orlando, USA) in combination with the LOGOS J (Milestone, Bergamo, Italy), a closed microwave-enhanced tissue processor, for overnight fixation, decalcification, and paraffin impregnation of the BMB. This allows next-day reporting without impaired morphology or immunohistochemistry, and even improved DNA quality of the BMB.

Indexed as

Bone marrow examinationDecalcification technique

Identifiers

PMID27398101

DOI10.1007/s12308-016-0270-y

PMCPMC4912573

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.