Evidence map›Paper›PMID 27398083›Full record

ArticleJournal of nanomaterials2016

Design of Nanoparticle-Based Carriers for Targeted Drug Delivery.

Xiaojiao Yu, Ian Trase, Muqing Ren, Kayla Duval, Xing Guo, Zi Chen

Abstract read
In one paragraph

Article in Journal of nanomaterials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed.

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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaojiao Yu *Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
Ian Trase *Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
Muqing RenDepartment of Chemical Physics, University of Science and Technology of China, Hefei, Anhui 230026, China.
Kayla DuvalThayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
Xing GuoThayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
Zi ChenThayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.

Funding

Epithelial layer jamming in breast cancer cell migrationU01CA202123 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J · 2015 to 2019
$3.4M
NCI NIH HHS U01 CA202123
6 · The paper itself

Abstract

Nanoparticles have shown promise as both drug delivery vehicles and direct antitumor systems, but they must be properly designed in order to maximize efficacy. Computational modeling is often used both to design new nanoparticles and to better understand existing ones. Modeled processes include the release of drugs at the tumor site and the physical interaction between the nanoparticle and cancer cells. In this article, we provide an overview of three different targeted drug delivery methods (passive targeting, active targeting and physical targeting), compare methods of action, advantages, limitations, and the current stage of research. For the most commonly used nanoparticle carriers, fabrication methods are also reviewed. This is followed by a review of computational simulations and models on nanoparticle-based drug delivery.

Indexed as

cancermultiscale modelingnanoparticle designself-assembly of nanoparticlestargeted drug delivery

Identifiers

PMID27398083
PMCPMC4936496

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.