ArticleBMC clinical pathology2016
Histopathological techniques for the diagnosis of combat-related invasive fungal wound infections.
Article in BMC clinical pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Sporotrichoid lymphocutaneous infection caused byMedical mycology case reports · 2026Article
- Histology-Correlated FTIR Chemical Imaging of Fungal Infection-Associated Tissue Compartments in Human Skin: A Proof-of-Concept Study.Diagnostics (Basel, Switzerland) · 2026Article
- Diagnostic odyssey of a German shepherd dog with disseminatedFrontiers in veterinary science · 2026Article
- Review
- Renaissance of an Emerging Pathogen-Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- A Seminested PCR Method for the Diagnosis of Invasive Fungal Infections in Combat Injured.Open forum infectious diseases · 2024Article
- Mucormycosis in Post Novel Corona Virus Patients: An Institutional Experience.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- A Lethal Case of DisseminatedJournal of fungi (Basel, Switzerland) · 2023Article
- Common condition with uncommon cause: fungal folliculitis in immunosuppressed patient with Blau syndrome.BMJ case reports · 2022Article
- Combat-Related Invasive Fungal Wound Infections.Military medicine · 2022Article
- Combat trauma-related invasive fungal wound infections.Current fungal infection reports · 2020Article
- Molecular Detection of Filamentous Fungi in Formalin-Fixed Paraffin-Embedded Specimens in Invasive Fungal Wound Infections Is Feasible with High Specificity.Journal of clinical microbiology · 2019Article
- After the Battlefield: Infectious Complications among Wounded Warriors in the Trauma Infectious Disease Outcomes Study.Military medicine · 2019Article
- Mucormycosis: A new threat to Coronavirus disease 2019 with special emphasis on India.Clinical epidemiology and global healthReview
- Histopathology of Hair Follicle Epithelium in Patients of Recurrent and Recalcitrant Dermatophytosis: A Diagnostic Cross-Sectional Study.International journal of trichologyArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEffective management of trauma-related invasive fungal wound infections (IFIs) depends on early diagnosis and timely initiation of treatment. We evaluated the utility of routine staining, histochemical stains and frozen section for fungal element identification.
methodsA total of 383 histopathological specimens collected from 66 combat-injured United States military personnel with IFIs were independently reviewed by two pathologists. Both periodic acid-Schiff (PAS) and Gomori methenamine silver (GMS) stains were used on 74 specimens. The performance of the two special stains was compared against the finding of fungal elements via any histopathological method (ie, special stains or hematoxylin and eosin). In addition, the findings from frozen sections were compared against permanent sections.
resultsThe GMS and PAS results were 84 % concordant (95 % confidence interval: 70 to 97 %). The false negative rate of fungal detection was 15 % for GMS and 44 % for PAS, suggesting that GMS was more sensitive; however, neither stain was statistically significantly superior for identifying fungal elements (p = 0.38). Moreover, 147 specimens had frozen sections performed, of which there was 87 % correlation with permanent sections (60 % sensitivity and 98 % specificity). In 27 permanent sections, corresponding cultures were available for comparison and 85 % concordance in general species identification was reported.
conclusionsThe use of both stains does not have an added benefit for identifying fungal elements. Furthermore, while the high specificity of frozen section may aid in timely IFI diagnoses, it should not be used as a stand-alone method to guide therapy due to its low sensitivity.
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