ArticleCurrent biology : CB2016
Identification of a Retinal Circuit for Recurrent Suppression Using Indirect Electrical Imaging.
Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Synaptic Inputs to OFF Parasol Ganglion Cells in Macaque Retina: An Analysis Using Serial Blockface Scanning Electron Microscopy.Brain sciences · 2026Article
- Amacrine cell inputs to OFF midget ganglion cells in macaque retina.The Journal of physiology · 2025Article
- Spatial Distribution and Morphology of CaMKII-Expressing Amacrine Cells in Marmoset, Macaque, and Human Retina.The Journal of comparative neurology · 2025Article
- Retinal ganglion cells encode the direction of motion outside their classical receptive field.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Synaptic inputs to broad thorny ganglion cells in macaque retina.The Journal of comparative neurology · 2021Article
- Feedback from retinal ganglion cells to the inner retina.PloS one · 2021Article
- Wide-field amacrine cell inputs to ON parasol ganglion cells in macaque retina.The Journal of comparative neurology · 2020Article
- Article
- Electrical Coupling of Heterotypic Ganglion Cells in the Mammalian Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Neural Mechanisms Mediating Motion Sensitivity in Parasol Ganglion Cells of the Primate Retina.Neuron · 2018Article
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8 authors.
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Abstract
Understanding the function of modulatory interneuron networks is a major challenge, because such networks typically operate over long spatial scales and involve many neurons of different types. Here, we use an indirect electrical imaging method to reveal the function of a spatially extended, recurrent retinal circuit composed of two cell types. This recurrent circuit produces peripheral response suppression of early visual signals in the primate magnocellular visual pathway. We identify a type of polyaxonal amacrine cell physiologically via its distinctive electrical signature, revealed by electrical coupling with ON parasol retinal ganglion cells recorded using a large-scale multi-electrode array. Coupling causes the amacrine cells to fire spikes that propagate radially over long distances, producing GABA-ergic inhibition of other ON parasol cells recorded near the amacrine cell axonal projections. We propose and test a model for the function of this amacrine cell type, in which the extra-classical receptive field of ON parasol cells is formed by reciprocal inhibition from other ON parasol cells in the periphery, via the electrically coupled amacrine cell network.
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