Evidence map›Paper›PMID 27397553›Full record

SynthesisInternational wound journal2017

Risk factors for periprosthetic joint infection following primary total hip or knee arthroplasty: a meta-analysis.

Lingde Kong, Junming Cao, Yingze Zhang, Wenyuan Ding, Yong Shen

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International wound journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07651462 (Preoperative Metabolic Optimization), which is not on this map. Cited by 105 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07651462 narecruitingnot on this mapstarted 2025, after this paper: background citation

Preoperative Metabolic Optimization: Influence of Intermittent and Buchinger-Type Fasting on the Gut Microbiome, Immune Profile, and Postoperative Complications in Patients Undergoing Primary Total Hip Arthroplasty - A Randomized Controlled Trial

TypeinterventionalSponsorCharite University, Berlin, GermanyRan2025 to 2026Enrolled130ConditionsHip Osteoarthritis, Arthroplasty, Replacement, Hip, Postoperative Complications, Surgical Wound InfectionArmsBuchinger Fastenbox + intermittent fasting (20-day preoperative schedule)
3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Machine Learning Based Diagnostic Models for Hip and Knee Prosthetic Joint Infection: A Systematic Review.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Antibiotics in Hand Surgery: Guidelines and Review.Journal of hand surgery global online · 2026
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. [Differential analysis of gut microbiome in patients with periprosthetic joint infection, aseptic failure, and osteoarthritis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Article
  17. Article
  18. Article
  19. Review
  20. Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lingde KongDepartment of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Hebei, P.R. China.
Junming CaoDepartment of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Hebei, P.R. China.
Yingze ZhangDepartment of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Hebei, P.R. China.
Wenyuan DingDepartment of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Hebei, P.R. China.
Yong ShenDepartment of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Hebei, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To identify risk factors for periprosthetic joint infection following primary total joint arthroplasty, a systematic search was performed in Pubmed, Embase and Cochrane library databases. Pooled odds ratios (ORs) or standardised mean differences (SMDs) with 95% confidence intervals (CIs) were calculated. Patient characteristics, surgical-related factors and comorbidities, as potential risk factors, were investigated. The main factors associated with infection after total joint arthroplasty (TJA) were male gender (OR, 1·48; 95% CI, 1.19-1.85), age (SMD, -0·10; 95% CI, -0.17--0.03), obesity (OR, 1·54; 95% CI, 1·25-1·90), alcohol abuse (OR, 1·88; 95% CI, 1·32-2·68), American Society of Anesthesiologists (ASA) scale > 2 (OR, 2·06; 95% CI, 1·77-2·39), operative time (SMD, 0·49; 95% CI, 0·19-0·78), drain usage (OR, 0·36; 95% CI, 0·18-0·74), diabetes mellitus (OR, 1·58; 95% CI, 1·37-1·81), urinary tract infection (OR, 1·53; 95% CI, 1.09-2.16) and rheumatoid arthritis (OR, 1·57; 95% CI, 1·30-1·88). Among these risk factors, ASA score > 2 was a high risk factor, and drain usage was a protective factor. There was positive evidence for some factors that could be used to prevent the onset of infection after TJA.

Indexed as

AdultAgedAged, 80 and overArthroplasty, Replacement, HipArthroplasty, Replacement, KneeFemaleHumansMaleMiddle AgedOsteoarthritisProsthesis-Related InfectionsReoperationRisk FactorsMeta-analysisPeriprosthetic joint infectionRisk factorSystematic reviewTotal joint arthroplasty

Identifiers

PMID27397553
PMCPMC7949746

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.