Observational studyRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2016
Dose-volume effect relationships for late rectal morbidity in patients treated with chemoradiation and MRI-guided adaptive brachytherapy for locally advanced cervical cancer: Results from the prospective multicenter EMBRACE study.
Observational study in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07164534 (A Phase III Trial to Assess the Effectiveness of NRF2 Activator), which is not on this map. Cited by 113 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase III Trial to Assess the Effectiveness of NRF2 Activator (Oral Sodium-copper- Chlophyllin ) in Locally Advanced Cervical Cancer to Reduce Late Radiotherapy Toxicity. (CHOC-LATE Trial)
Who cites it
113 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Hyperbaric oxygen therapy for radiation enteritis and clinical parameters: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Impact of intracavitary brachytherapy technique (2D versus 3D) on outcomes of cervical cancer: a systematic review and meta-analysis.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2020Pooled it
- Prediction of mucositis risk secondary to cancer therapy: a systematic review of current evidence and call to action.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Pooled it
- Radiation Therapy for Cervical Cancer: Executive Summary of an ASTRO Clinical Practice Guideline.Practical radiation oncologyGuideline
- Impact of Saccharomyces boulardii on acute gastrointestinal toxicities in patients undergoing pelvic radiotherapy for gynecologic cancers: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Trial
- Effect of interval between preoperative radiotherapy and surgery on clinical outcome and radiation proctitis in rectal cancer from FOWARC trial.Cancer medicine · 2020Trial
- Comparison of outcomes for MR-guided versus CT-guided high-dose-rate interstitial brachytherapy in women with locally advanced carcinoma of the cervix.Gynecologic oncology · 2017Trial
- Dosimetric impact of intrarectal gas removal by Foley catheter on image-guided adaptive brachytherapy in cervical cancer patients.Journal of contemporary brachytherapy · 2026Article
- Dosimetric impact of computed tomography slice thickness-induced applicator reconstruction uncertainties in three-dimensional brachytherapy for cervical cancer.Journal of contemporary brachytherapy · 2026Article
- Article
- Stabilised Hyaluronic Acid Gel Rectal Spacers in MRI-Guided Brachytherapy for Gynaecological Cancers: A Prospective Feasibility Study.Journal of medical radiation sciences · 2026Article
- A bibliometric analysis of global research in cervical cancer radiotherapy (2015-2024): trends, hotspots, and future directions.Translational cancer research · 2026Article
- Dosimetric comparison between brachytherapy and MR-Linac as a boost modality for locally advanced cervical cancer.Clinical and translational radiation oncology · 2026Article
- Impact of the locking function of hybrid inverse planning optimization on the treatment plan quality of intracavitary/interstitial brachytherapy for locally advanced cervical cancer.Radiological physics and technology · 2026Article
- Review
- Impact of rectal gas evacuation on dosimetry and applicator displacement in cervical cancer brachytherapy.Journal of applied clinical medical physics · 2026Article
- Rectovaginal fistulas after radiation therapy: treatment options and outcomes - a narrative review.Frontiers in oncology · 2026Review
- Risk factors and clinical outcomes of radiation-induced fistula after chemoradiation and image-guided brachytherapy for locally advanced cervical cancer.Gynecologic oncology reports · 2025Article
- The use of transrectal ultrasound to improve gynecologic interstitial applicator implantation.Gynecologic oncology · 2025Article
- Dosimetric impact of dose constraint indications using individual patient dose management system for brachytherapy in cervical cancer.Journal of contemporary brachytherapy · 2025Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo establish dose volume-effect relationships predicting late rectal morbidity in cervix cancer patients treated with concomitant chemoradiation and MRI-guided adaptive brachytherapy (IBABT) within the prospective EMBRACE study. MATERIAL AND
methodAll patients were treated with curative intent according to institutional protocols with chemoradiation and IGABT. Reporting followed the GEC-ESTRO recommendations ( [Formula: see text] , [Formula: see text] ), applying bioeffect modeling (linear quadratic model) with equieffective doses (EQD2
results960 patients were included. The median follow-up was 25.4months. Twenty point one percent of the patients had grade 1 events, 6.0% grade 2, 1.6% grade 3 and 0.1%, grade 4. The mean D
conclusionsSignificant correlations were established between late rectal morbidity, overall and single endpoints, and dose-volume ( [Formula: see text] , [Formula: see text] ) and dose-point (D
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.