Evidence map›Paper›PMID 27396440›Full record

ArticleThe Journal of physiology2017

Superior mitochondrial adaptations in human skeletal muscle after interval compared to continuous single-leg cycling matched for total work.

Martin J MacInnis, Evelyn Zacharewicz, Brian J Martin, Maria E Haikalis, Lauren E Skelly, Mark A Tarnopolsky, Robyn M Murphy, Martin J Gibala

2 registry-linked trialsOpen access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 109 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 6 pooled it
45.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07084298 early_phase1not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effects of 12 Weeks of Oral Iron Supplementation on Skeletal Muscle Iron Content, Mitochondrial Function, and Indices of Aerobic Fitness in Healthy Females With Suboptimal Iron Stores

TypeinterventionalSponsorUniversity of CalgaryRan2025 to 2026Enrolled36ConditionsIron DeficiencyArmsOral iron supplement, Placebo
NCT07450690 narecruitingnot on this mapstarted 2026, after this paper: background citation

Deciphering Muscle-Nerve Communication Via Mitochondrial Myopathy Insights: Exploring the Effects of Exercise Training

TypeinterventionalSponsorUniversity of CopenhagenRan2026 to 2030Enrolled22ConditionsMitochondrial Diseases, Mitochondrial MyopathyArmsUnilateral high-intensity interval training (HIIT)
3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 6 syntheses or guidelines pooled it, 212 citations in OpenAlex.

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  13. Mitochondrial respiration variability and simulations in human skeletal muscle: The Gene SMART study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
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49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Martin J MacInnisDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Evelyn ZacharewiczDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
Brian J MartinDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Maria E HaikalisDepartment of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada.
Lauren E SkellyDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Mark A TarnopolskyDepartment of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada.
Robyn M MurphyDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
Martin J GibalaDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
McMaster University · CALa Trobe University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

key pointsA classic unresolved issue in human integrative physiology involves the role of exercise intensity, duration and volume in regulating skeletal muscle adaptations to training. We employed counterweighted single-leg cycling as a unique within-subject model to investigate the role of exercise intensity in promoting training-induced increases in skeletal muscle mitochondrial content. Six sessions of high-intensity interval training performed over 2 weeks elicited greater increases in citrate synthase maximal activity and mitochondrial respiration compared to moderate-intensity continuous training matched for total work and session duration. These data suggest that exercise intensity, and/or the pattern of contraction, is an important determinant of exercise-induced skeletal muscle remodelling in humans. ABSTRACT: We employed counterweighted single-leg cycling as a unique model to investigate the role of exercise intensity in human skeletal muscle remodelling. Ten young active men performed unilateral graded-exercise tests to measure single-leg V̇O2, peak and peak power (W

Indexed as

Adaptation, PhysiologicalElectron TransportHigh-Intensity Interval TrainingHumansLegMaleMitochondria, MuscleMuscle, SkeletalOxidative PhosphorylationOxygen ConsumptionYoung Adultexercise intensityhigh-intensity interval trainingmuscle fibre

Identifiers

PMID27396440
PMCPMC5407978
OpenAlexW2470470829

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.