ArticleJournal of periodontal research2017
Laser-activated transforming growth factor-β1 induces human β-defensin 2: implications for laser therapies for periodontitis and peri-implantitis.
Article in Journal of periodontal research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Improving Titanium Implant Stability with Photobiomodulation: A Review and Meta-Analysis of Irradiation Parameters.Photobiomodulation, photomedicine, and laser surgery · 2023Pooled it
- Management of peri-implantitis using a diode laser (810 nm) vs conventional treatment: a systematic review.Lasers in medical science · 2021Pooled it
- A randomised clinical trial comparing a surgical approach for treatment of peri-implantitis to non-surgical debridement with adjunctive diode laser therapy.Clinical oral investigations · 2025Trial
- Article
- Laser-Mediated Hemostasis for Older Patients Receiving Routine Dental Treatment.Dentistry journal · 2025Article
- Effectiveness of 808 nm Near Infrared (NIR) Laser Photobiomodulation for Accelerating Postoperative Wound Healing.Journal of lasers in medical sciences · 2025Article
- Photobiomodulation therapy.JADA foundational science · 2025Review
- The Efficacy of Er:YAG Laser in the Extraction of Impacted Third Molars: A Randomized Clinical Trial.Dentistry journal · 2024Article
- A novel investigational preclinical model to assess fluence rate for dental oral craniofacial tissues.Photodiagnosis and photodynamic therapy · 2024Article
- Article
- Laser Biostimulation Induces Wound Healing-Promoter β2-Defensin Expression in Human Keratinocytes via Oxidative Stress.Antioxidants (Basel, Switzerland) · 2023Article
- Photobiomodulation in dental extraction therapy: Postsurgical pain reduction and wound healing.Journal of the American Dental Association (1939) · 2023Review
- Induction of Endogenous Antimicrobial Peptides to Prevent or Treat Oral Infection and Inflammation.Antibiotics (Basel, Switzerland) · 2023Review
- Photonics-based treatments: Mechanisms and applications in oral infectious diseases.Frontiers in microbiology · 2023Review
- Review
- In vitro effects of photobiomodulation applied to gingival fibroblasts cultured on titanium and zirconia surfaces and exposed to LPS from Escherichia coli.Lasers in medical science · 2020Article
- In Vitro Cytological Responses against Laser Photobiomodulation for Periodontal Regeneration.International journal of molecular sciences · 2020Review
- Acute exposure of 532 nm laser differentially regulates skin tissue transcription factors.PloS one · 2020Article
- Q-Switch Nd:YAG Laser-Assisted Decontamination of Implant Surface.Dentistry journal · 2019Article
- Photobiomodulation therapy modulates epigenetic events and NF-κB expression in oral epithelial wound healing.Lasers in medical science · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThere is increasing popularity of high-power lasers for surgical debridement and antimicrobial therapy in the management of peri-implantitis and periodontal therapy. Removal of the noxious foci would naturally promote tissue healing directly. However, there are also anecdotal reports of better healing around routine high-power laser procedures. The precise mechanisms mediating these effects remain to be fully elucidated. This work examines these low-dose laser bystander effects on oral human epithelial and fibroblasts, particularly focusing on the role of human β-defensin 2 (HBD-2 or DEFB4A), a potent factor capable of antimicrobial effects and promoting wound healing. MATERIAL AND
methodsLaser treatments were performed using a near-infrared laser (810 nm diode) at low doses. Normal human oral keratinocytes and fibroblast cells were used and HBD-2 mRNA and protein expression was assessed with real time polymerase chain reaction, western blotting and immunostaining. Role of transforming growth factor (TGF)-β1 signaling in this process was dissected using pathway-specific small molecule inhibitors.
resultsWe observed laser treatments robustly induced HBD-2 expression in an oral fibroblast cell line compared to a keratinocyte cell line. Low-dose laser treatments results in activation of the TGF-β1 pathway that mediated HBD-2 expression. The two arms of TGF-β1 signaling, Smad and non-Smad are involved in laser-mediated HBD-2 expression.
conclusionsLaser-activated TGF-β1 signaling and induced expression of HBD-2, both of which are individually capable of promoting healing in tissues adjacent to high-power surgical laser applications. Moreover, the use of low-dose laser therapy itself can provide additional therapeutic benefits for effective clinical management of periodontal or peri-implant disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.