ArticleCortex; a journal devoted to the study of the nervous system and behavior2016
Apolipoprotein ɛ4 breaks the association between declarative long-term memory and memory-based orienting of spatial attention in middle-aged individuals.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Comparing the impact of contextual associations and statistical regularities in visual search and attention orienting.PloS one · 2024Article
- Memory precision of object-location binding is unimpaired inBrain communications · 2021Article
- Short-term memory advantage for brief durations in human APOE ε4 carriers.Scientific reports · 2020Article
- Impaired memory-guided attention in asymptomatic APOE4 carriers.Scientific reports · 2019Article
- The functional consequences of social attention on memory precision and on memory-guided orienting in development.Developmental cognitive neuroscience · 2019Article
- Dissociable effects of the apolipoprotein-E (APOE) gene on short- and long-term memories.Neurobiology of aging · 2019Article
- Using event-related fMRI to examine sustained attention processes and effects of APOE ε4 in young adults.PloS one · 2018Article
- Exploring biased attention towards body-related stimuli and its relationship with body awareness.Scientific reports · 2017Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
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Abstract
Apolipoprotein (APOE) ɛ4 genotype has been identified as a risk factor for late-onset Alzheimer disease (AD). The memory system is mostly involved in AD, and memory deficits represent its key feature. A growing body of studies has focused on the earlier identification of cognitive dysfunctions in younger and older APOE ɛ4 carriers, but investigation on middle-aged individuals remains rare. Here we sought to investigate if the APOE ɛ4 genotype modulates declarative memory and its influences on perception in the middle of the life span. We tested 60 middle-aged individuals recruited according to their APOE allele variants (ɛ3/ɛ3, ɛ3/ɛ4, ɛ4/ɛ4) on a long-term memory-based orienting of attention task. Results showed that the APOE ɛ4 genotype impaired neither explicit memory nor memory-based orienting of spatial attention. Interestingly, however, we found that the possession of the ɛ4 allele broke the relationship between declarative long-term memory and memory-guided orienting of visuo-spatial attention, suggesting an earlier modulation exerted by pure genetic characteristics on cognition. These findings are discussed in light of possible accelerated brain ageing in middle-aged ɛ4-carriers, and earlier structural changes in the brain occurring at this stage of the lifespan.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.