SynthesisClinical autonomic research : official journal of the Clinical Autonomic Research Society2016
A meta-analysis of HIV and heart rate variability in the era of antiretroviral therapy.
Synthesis in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Trial
- Reduced 24-hour heart rate variability in neurosyphilis: a retrospective case-control study.Frontiers in neurology · 2026Article
- Wearable device monitoring of HIV health in the face of climate change and weather exposures: protocol for a mixed-methods study.BMJ open · 2025Article
- TheU-shape association between on-admission resting heart rate and 60-day all-cause mortality of AIDS inpatients in Fujian China: a retrospective cohort study.AIDS research and therapy · 2024Article
- Reduced heart rate variability is associated with altered clinical laboratory profile in people living with HIV.Brain, behavior, & immunity - health · 2024Article
- HIV status affects PTSD symptom severity, psychophysiology, and heart rate variability in women with low but not high exposure to childhood maltreatment.Stress (Amsterdam, Netherlands) · 2024Article
- Blood pressure changes during tenofovir-based antiretroviral therapy among people living with HIV in Lilongwe, Malawi: results from the prospective LighTen Cohort Study.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Autonomic Neuropathy as a Predictor of Morbidity and Mortality in People Living With HIV: A Retrospective, Longitudinal Cohort Study.Neurology. Clinical practice · 2023Article
- Article
- Article
- Prevention of heart failure, tachyarrhythmias and sudden cardiac death in HIV.Current opinion in HIV and AIDS · 2022Review
- Article
- Recreational Exercising and Self-Reported Cardiometabolic Diseases in German People Living with HIV: A Cross-Sectional Study.International journal of environmental research and public health · 2021Article
- Association between exposure to Efavirenz and substrates of dysrhythmia in HIV-infected young adults.Clinical cardiology · 2021Article
- Linear and non-linear analysis of heart rate variability in HIV-positive patients on two different antiretroviral therapy regimens.BMC infectious diseases · 2021Article
- The Effects of Acute Aerobic Exercise on Blood Pressure, Arterial Function, and Heart Rate Variability in Men Living With HIV.Frontiers in physiology · 2021Article
- Heart Rate Variability, HIV and the Risk of Cardiovascular Diseases in Rural South Africa.Global heart · 2020Article
- Hypertension Risk with Abacavir Use among HIV-Infected Individuals: A Nationwide Cohort Study.Yonsei medical journal · 2018Article
- HIV Infection and Risk of Cardiovascular Diseases Beyond Coronary Artery Disease.Current atherosclerosis reports · 2017Review
- The Intersection of Cognitive Ability and HIV: A Review of the State of the Nursing Science.The Journal of the Association of Nurses in AIDS Care : JANACReview
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeart rate variability (HRV) has been used to assess autonomic dysfunction since the beginning of the HIV epidemic. Although autonomic failure was commonly detected in HIV and AIDS patients prior to the advent of antiretroviral therapy (ART), the effect of HIV on HRV in the current era of widespread ART availability is more ambiguous.
methodsA systematic search and review was conducted on cross-sectional observational and case-control studies published in the era of ART (1996-2015) that compared HRV between HIV + individuals treated with ART and HIV - controls. Eight out of the 20 studies identified, enrolling a total of 292 HIV + adults (mean age 38.7 years) and 201 HIV seronegative controls (mean age 35.1 years), were included in a meta-analysis based on stringent methodological criteria.
resultsAt rest, individuals with HIV showed lower HRV in the time (g) = -0.72, 95 % CI (-1.03 to -0.42) and low-frequency (LF) domain (g) = -0.51, (-0.81 to -0.21); markers of lower parasympathetic tone in the time (g) = -0.55, (-0.85 to -0.25) and high-frequency (HF) domain (g) = -0.42, (-0.71 to -0.12); and higher LF:HF ratio (g) = 0.46, (0.12-0.86) in the frequency domain, suggestive of parasympathetic withdrawal.
conclusionThis meta-analysis confirmed, within a relatively young cohort of HIV + adults on ART, a general reduction in autonomic function with a shift toward sympathetic dominance. This shift may predispose HIV patients to early and elevated risk of arrhythmias, cardiac events, and accelerated HIV disease progression.
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