Evidence map›Paper›PMID 27395385›Full record

Trial reportMaternal and child health journal2016

Provision of Lipid-Based Nutrient Supplements from Age 6 to 18 Months Does Not Affect Infant Development Scores in a Randomized Trial in Malawi.

Elizabeth L Prado, John Phuka, Kenneth Maleta, Per Ashorn, Ulla Ashorn, Steve A Vosti, Kathryn G Dewey

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Maternal and child health journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00945698 (A Two-centre, Randomised, Single-blind, Parallel Group Controlled Trial, Testing the Growth Promoting Effect of Long-term Complementary Feeding of Infants With Different Doses and Formulations of Lipid-based Nutrient Supplements), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00945698 phase3completednot on this map

A Two-centre, Randomised, Single-blind, Parallel Group Controlled Trial, Testing the Growth Promoting Effect of Long-term Complementary Feeding of Infants With Different Doses and Formulations of Lipid-based Nutrient Supplements (LNS)

TypeinterventionalSponsorTampere UniversityRan2009 to 2014Enrolled1,920ConditionsMalnutritionArmsLipid-based nutrient supplement, 10gM, Lipid-based nutrient supplement, 20gM, Lipid-based Nutrient Supplement, 20gNoM, Lipid-based nutrient supplement, 40gM, Lipid-based Nutrient Supplement, 40gNoM
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elizabeth L PradoProgram in International and Community Nutrition, Department of Nutrition, University of California Davis, 3253 Meyer Hall, One Shields Ave, Davis, CA, 95616, USA. elprado@ucdavis.edu.
John PhukaSchool of Public Health and Family Medicine, College of Medicine, University of Malawi, Blantyre, Malawi.
Kenneth MaletaSchool of Public Health and Family Medicine, College of Medicine, University of Malawi, Blantyre, Malawi.
Per AshornDepartment for International Health, University of Tampere School of Medicine, Tampere, Finland.
Ulla AshornDepartment for International Health, University of Tampere School of Medicine, Tampere, Finland.
Steve A VostiDepartment of Agricultural and Resource Economics, University of California Davis, Davis, CA, USA.
Kathryn G DeweyProgram in International and Community Nutrition, Department of Nutrition, University of California Davis, 3253 Meyer Hall, One Shields Ave, Davis, CA, 95616, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives Undernutrition during early life contributes to more than 200 million children globally not fulfilling their developmental potential. Our objective was to determine whether dietary supplementation with several formulations of lipid-based nutrient supplements (LNS), which differed in dose per day and milk content, positively affect infant development in Malawi. Methods We randomly assigned 1932 infants age 6 months to receive one of the following for 12 months: 10, 20 g, or 40 g/day milk-containing LNS, 20 g or 40 g/day milk-free LNS, or no supplement until 18 months of age (control group). We assessed motor, language, socio-emotional, and executive function at age 18 months. Primary analysis was by intention-to-treat and we also examined 13 potential effect modifiers, including the child's initial nutritional status and level of developmental stimulation. The study is registered as clinical trial NCT00945698. Results We found no significant differences between intervention groups in any scores. The difference in mean z-scores between children in the control group and children in the intervention groups ranged from -0.08 to 0.04 for motor development (p = 0.76), -0.05 to 0.01 for language development (p = 0.97), -0.15 to 0.11 for socio-emotional development (p = 0.22), and -0.02 to 0.20 for executive function (p = 0.24). We did not find that initial nutritional status, developmental stimulation, or other factors modified the effect LNS versus control group. Conclusions for Practice Our results suggest that in a population such as this one, provision of LNS from age 6 to 18 months would not affect motor, language, socio-emotional, or executive function skills at age 18 months.

Indexed as

Dietary SupplementsFood, FortifiedAdultAge FactorsAnimalsChild DevelopmentCognitionFemaleHumansInfantLipidsMalawiMaleMicronutrientsMilkMotor SkillsLipidsMicronutrientsExecutive functioniLiNS projectInfant developmentLanguage developmentLipid-based nutrient supplementsMotor developmentSocio-emotional development

Identifiers

PMID27395385

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.