ArticleBiological psychiatry2016
Elevated Amygdala Perfusion Mediates Developmental Sex Differences in Trait Anxiety.
Article in Biological psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- Functional brain alterations in anxious depression: Insights from whole-brain fMRI and meta-analysis.Dialogues in clinical neuroscience · 2026Pooled it
- Myo-Inositol Deficiency, Structural Brain Changes, and Cerebral Perfusion Alterations in Classic Galactosemia: Preliminary Insights From a Multiparametric MRI Study.Journal of inherited metabolic disease · 2025Article
- Reproducible sex differences in personalised functional network topography in youth.The British journal of psychiatry : the journal of mental science · 2025Article
- Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes.Nature genetics · 2025Article
- The association of sex and attitudes towards parental migration with anxiety symptoms in left-behind children: a large-scale cross-sectional study.Frontiers in psychiatry · 2025Article
- Sex Differences in the Neurobiology of Fear and Anxiety.Current topics in behavioral neurosciences · 2025Review
- The Limbic System in Co-Occurring Substance Use and Anxiety Disorders: A Narrative Review Using the RDoC Framework.Brain sciences · 2024Review
- An Honest Reckoning With the Amygdala and Mental Illness.The American journal of psychiatry · 2024Review
- Mood, Quality of Life, and Immune Fitness During the COVID-19 Pandemic of Young Adults in Germany.Journal of clinical medicine · 2024Article
- A Method to Estimate Longitudinal Change Patterns in Functional Network Connectivity of the Developing Brain Relevant to Psychiatric Problems, Cognition, and Age.Brain connectivity · 2024Article
- A Gender-Based Point of View in Pediatric Neurology.Journal of personalized medicine · 2023Review
- Heart-brain interactions in cardiac and brain diseases: why sex matters.European heart journal · 2022Review
- The Amygdala and Depression: A Sober Reconsideration.The American journal of psychiatry · 2022Article
- Article
- Sex-dependent role of CD300f immune receptor in generalized anxiety disorder.Brain, behavior, & immunity - health · 2021Article
- Anxiety Symptoms Are Associated With Higher Psychological Stress, Poor Sleep, and Inadequate Sleep Hygiene in Collegiate Young Adults-A Cross-Sectional Study.Frontiers in psychiatry · 2021Article
- Sex Differences in Variability of Brain Structure Across the Lifespan.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Anxiety in transition: Neuroendocrine mechanisms supporting the development of anxiety pathology in adolescence and young adulthood.Frontiers in neuroendocrinology · 2019Review
- Beyond a Binary Classification of Sex: An Examination of Brain Sex Differentiation, Psychopathology, and Genotype.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Article
- Trauma-associated anterior cingulate connectivity during reward learning predicts affective and anxiety states in young adults.Psychological medicine · 2019Article
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20 authors at 3 institutions in 1 country.
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Abstract
backgroundAdolescence is a critical period for emotional maturation and is a time when clinically significant symptoms of anxiety and depression increase, particularly in females. However, few studies relate developmental differences in symptoms of anxiety and depression to brain development. Cerebral blood flow is one brain phenotype that is known to have marked developmental sex differences.
methodsWe investigated whether developmental sex differences in cerebral blood flow mediated sex differences in anxiety and depression symptoms by capitalizing on a large sample of 875 youths who completed cross-sectional imaging as part of the Philadelphia Neurodevelopmental Cohort. Perfusion was quantified on a voxelwise basis using arterial spin-labeled magnetic resonance imaging at 3T. Perfusion images were related to trait and state anxiety using general additive models with penalized splines, while controlling for gray matter density on a voxelwise basis. Clusters found to be related to anxiety were evaluated for interactions with age, sex, and puberty.
resultsTrait anxiety was associated with elevated perfusion in a network of regions including the amygdala, anterior insula, and fusiform cortex, even after accounting for prescan state anxiety. Notably, these relationships strengthened with age and the transition through puberty. Moreover, higher trait anxiety in postpubertal females was mediated by elevated perfusion of the left amygdala.
conclusionsTaken together, these results demonstrate that differences in the evolution of cerebral perfusion during adolescence may be a critical element of the affective neurobiological characteristics underlying sex differences in anxiety and mood symptoms.
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