ArticleInternational archives of occupational and environmental health2016
Evaluation of biomarkers assessing regular alcohol consumption in an occupational setting.
Article in International archives of occupational and environmental health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Alcohol Consumption at Work in Construction Workers Employed in Small Italian Companies.La Medicina del lavoro · 2026Article
- Urinary Ethyl Glucuronide Can Be Used as a Biomarker of Habitual Alcohol Consumption in the General Population.The Journal of nutrition · 2019Article
- Cross-sectional study on N,N-dimethylformamide (DMF); effects on liver and alcohol intolerance.International archives of occupational and environmental health · 2016Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAn estimation of ethanol intake is frequently of importance in the frame work of studies, but not trivial to achieve. Problems are "underreporting", a very short time frame for the detection of ethanol as direct marker and interference of many in- and outside body factors with strain parameters. The aim of this study was to explore the suitability of the direct urinary biomarkers ethyl glucuronide (EtG) and ethyl sulphate (EtS) to assess moderate but regular alcohol consumption. MATERIALS AND
methodsA total of 175 male workers without any known occupational contact to substances influencing liver functions or metabolism of ethanol were examined. Strain parameters of alcohol consumption, i.e. the liver function tests (LFTs: aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase), carbohydrate-deficient transferrin (CDT), mean corpuscular erythrocyte volume (MCV) and the markers of alcohol consumption (EtG and EtS) have been analysed and compared.
resultsUp to 14 % of workers had been outside reference range for strain parameters. 62.3 % of the workers had at least traceable amounts of EtG and 84.6 % of EtS. Values above cut-off (indicating voluntary ethanol intake) were found in 34.9 and 51.4 % of the workers for EtG and EtS, respectively. In multiple linear regression analyses, CDT and MCV but not the LFTs showed a dependency from the non-oxidative ethanol metabolites. The LFTs were influenced by BMI.
conclusionDetermination of EtG and EtS in urine is an adequate tool to assess moderate but regular alcohol consumption.
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