Evidence map›Paper›PMID 27394699›Full record

ReviewImmunology letters2016

Diversity and function of group 1 innate lymphoid cells.

Victor S Cortez, Marco Colonna

Open access · greenAbstract readReview
In one paragraph

Review in Immunology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.

  1. Effects of Air Pollution on Lung Innate Lymphoid Cells: Review of In Vitro and In Vivo Experimental Studies.International journal of environmental research and public health · 2019
    Pooled it
  2. Review
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  15. Correlation of caecal microbiome endotoxins genes and intestinal immune cells inFrontiers in cellular and infection microbiology · 2024
    Article
  16. Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Inflammatory Cues Direct Skin-Resident Type 1 Innate Lymphoid Cells to Adopt a Psoriasis-Promoting Identity.JID innovations : skin science from molecules to population health · 2023
    Article
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Victor S CortezDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA. Electronic address: mcolonna@pathology.wustl.edu.
Washington University in St. Louis · US

Funding

Mucosal Immune Defense Mechanisms of the Urinary BladderU01AI095542 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, HULTGREN, SCOTT J. · 2011 to 2020
$9.8M
The role of TGFbeta in development and function of salivary gland innate lymphoid cellsR01DE025884 · NIDCR · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, WEISMAN, GARY ANDREW · 2017 to 2021
$3.5M
THE ROLE OF NK-22 CELLS IN ANTI-HIV-1 MUCOSAL IMMUNITYR01DE021255 · NIDCR · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2010 to 2014
$1.9M
CRTAM-CADM1 INTERACTION IN THE BIOLOGY OF GUT LYMPHOCYTESR01DK103039 · NIDDK · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2015 to 2018
$1.4M
NIAID NIH HHS U01 AI095542NIDCR NIH HHS R01 DE021255NIDCR NIH HHS R01 DE025884NIDDK NIH HHS R01 DK103039
6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) are a heterogeneous population of cells with diverse roles in immune responses. Three major groups of ILCs have been defined on the basis of similarity in their production of signature cytokines, developmental requirements, and phenotypic markers. Group 1 ILCs produce IFN-γ, express the T-box transcription factors (TF) T-bet and/or Eomesodermin (Eomes), group 2 ILCs secrete IL-5 and IL-13 and express the TF GATA-3, while group 3 ILCs produce IL-22 and IL-17 and express the TF RORgt. In this review, we will briefly overview each group in terms of phenotype, function and development and then focus more extensively on group 1 ILCs, expanding on their emerging diversity, their disparate functions and the differences between NK cells and ILC1.

Indexed as

Immunity, InnateAnimalsBiomarkersCell DifferentiationCell PlasticityCytokinesDisease SusceptibilityGene Expression Regulation, DevelopmentalHumansInterferon-gammaKiller Cells, NaturalLymphocyte SubsetsOrgan SpecificityPhenotypeTranscription FactorsBiomarkersCytokinesInterferon-gammaTranscription FactorsILCInnate immunityInterferon-gammaNK cells

Identifiers

PMID27394699
PMCPMC5658203
OpenAlexW2474544116

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.