ArticlePediatric blood & cancer2016
Cognitive functioning in children from Nigeria with sickle cell anemia.
Article in Pediatric blood & cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Neurocognitive gains among Ugandan children with sickle cell anemia on hydroxyurea: 18-month interim trial results.Blood advances · 2025Trial
- Neurocognitive functioning of patients with sickle cell disease in low- and middle-income countries.Blood global hematology · 2025Article
- Statistical exploration of factors associated with birth of children having sickle cell traits among reproductive-age women in Nigeria.BMC public health · 2025Article
- Neurocognitive Impairment in Ugandan Children with Sickle Cell Anemia Compared to Sibling Controls: A cross-sectional study.medRxiv : the preprint server for health sciences · 2024Article
- Neurocognitive impairment in Ugandan children with sickle cell anemia compared to sibling controls: a cross-sectional study.Frontiers in stroke · 2024Article
- Sickle cell disease and social determinants of health: A scoping review.Pediatric blood & cancer · 2023Article
- Comprehensive assessment of cognitive function in adults with moderate and severe sickle cell disease.American journal of hematology · 2022Article
- Dementia in Africa: Current evidence, knowledge gaps, and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Review
- Prevalence and risk factors of cognitive impairment in children with sickle cell disease in Egypt.International journal of hematology · 2022Article
- Nutritional perspectives on sickle cell disease in Africa: a systematic review.BMC nutrition · 2021Article
- Social-environmental factors and cognitive and behavioral functioning in pediatric sickle cell disease.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2020Article
- Burden of neurological and neurocognitive impairment in pediatric sickle cell anemia in Uganda (BRAIN SAFE): a cross-sectional study.BMC pediatrics · 2019Article
- Associations of transcranial doppler velocity, age, and gender with cognitive function in children with sickle cell anemia in Nigeria.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2019Article
- Article
- Disease severity and slower psychomotor speed in adults with sickle cell disease.Blood advances · 2017Article
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5 authors.
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Abstract
backgroundCognitive impairment is a major neurological complication of sickle cell anemia (SCA) in the United States, but there are limited studies of cognitive impairment in Nigeria, the country with the highest SCA burden. We hypothesized that children from Nigeria with SCA have worse cognitive functioning than comparison children and explored the association between lower cognitive functioning and key laboratory demographic and socioeconomic variables among children with SCA. PROCEDURE: We conducted a cross-sectional survey, supplemented by anthropomorphic and laboratory data, among a convenience sample of children from Nigeria with and without SCA. We administered the Wechsler Intelligence Scale for Children, Version IV. Our primary outcome measures included (1) estimated IQ (Est. IQ), (2) working memory (WM), and (3) processing speed (PS).
resultsThe sample included 56 children with SCA (mean age 9.20 [SD 2.75], 46.43% girls) and 44 comparison children (mean age 9.41 [SD 2.49], 40.91% girls). Children with SCA performed worse on Est. IQ (84.58 vs. 96.10, P = 0.006) and PS (86.69 vs 96.91, P = 0.009) than comparison children. There was no significant difference in WM between both groups. Factors associated with lower Est. IQ and PS among children with SCA included age, maternal education, weight-for-age Z scores, and height-for age Z scores.
conclusionIn this small sample of children from Nigeria, we found worse cognitive functioning in children with SCA than in comparison children, and that sociodemographic and anthropomorphic factors were correlated with cognitive functioning.
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