ReviewCurrent opinion in biotechnology2016
Extracting structural and functional features of widely distributed biological circuits with single cell resolution via tissue clearing and delivery vectors.
Review in Current opinion in biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- A novel workflow for multi-modal imaging of musculoskeletal tissues.Journal of anatomy · 2025Article
- Promotion effect of TGF-β-Zfp423-ApoD pathway on lip sensory recovery after nerve sacrifice caused by nerve collateral compensation.International journal of oral science · 2023Article
- A method for ultrafast tissue clearing that preserves fluorescence for multimodal and longitudinal brain imaging.BMC biology · 2022Article
- Article
- Recent advances in stem cell therapy for neurodegenerative disease: Three dimensional tracing and its emerging use.World journal of stem cells · 2021Review
- Can Developments in Tissue Optical Clearing Aid Super-Resolution Microscopy Imaging?International journal of molecular sciences · 2021Review
- Pancreas Optical Clearing and 3-D Microscopy in Health and Diabetes.Frontiers in endocrinology · 2021Review
- A 3D atlas of the dynamic and regional variation of pancreatic innervation in diabetes.Science advances · 2020Article
- Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues.Nature communications · 2020Article
- Tissue clearing and its applications in neuroscience.Nature reviews. Neuroscience · 2020Review
- Article
- mSphere of Influence: Clearing a Path for High-Resolution Visualization of Host-Pathogen InteractionsmSphere · 2019Article
- Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies.Nature communications · 2019Article
- Systemic AAV vectors for widespread and targeted gene delivery in rodents.Nature protocols · 2019Article
- Whole-Brain Analysis of Cells and Circuits by Tissue Clearing and Light-Sheet Microscopy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex.Journal of visualized experiments : JoVE · 2018Article
- Tissue clearing of both hard and soft tissue organs with the PEGASOS method.Cell research · 2018Article
- Hydrogel-Tissue Chemistry: Principles and Applications.Annual review of biophysics · 2018Review
- Concepts in Light Microscopy of Viruses.Viruses · 2018Review
- A hybridization-chain-reaction-based method for amplifying immunosignals.Nature methods · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The scientific community has learned a great deal from imaging small and naturally transparent organisms such as nematodes and zebrafish. The consequences of genetic mutations on their organ development and survival can be visualized easily and with high-throughput at the organism-wide scale. In contrast, three-dimensional information is less accessible in mammalian subjects because the heterogeneity of light-scattering tissue elements renders their organs opaque. Likewise, genetically labeling desired circuits across mammalian bodies is prohibitively slow and costly via the transgenic route. Emerging breakthroughs in viral vector engineering, genome editing tools, and tissue clearing can render larger opaque organisms genetically tractable and transparent for whole-organ cell phenotyping, tract tracing and imaging at depth.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.