Evidence map›Paper›PMID 27393566›Full record

SynthesisNeuropsychology review2016

Functional Disability in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.

Cutter A Lindbergh, Rodney K Dishman, L Stephen Miller

2 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neuropsychology review, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 102 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06631742 narecruitingnot on this mapstarted 2024, after this paper: background citation

The Effect of an Exergaming Intervention on Physical Activity and Sleep in People With Major Neurocognitive Disorders Living in Long-term Care Facilities: a Pilot Randomized Controlled Trial.

TypeinterventionalSponsorEastern Switzerland University of Applied SciencesRan2024 to 2027Enrolled48ConditionsMajor Neurocognitive Disorder, Alzheimer Disease, Parkinson Disease, Lewy Body DementiaArmsExergaming on Dividat Senso, Usual Care
NCT07332169 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Efficacy of Non-invasive Brain Stimulation on Cognitive Functions in Patients With Chronic Obstructive Pulmonary Disease: Double-Blinded Randomised Controlled Trial

TypeinterventionalSponsorShahad Abdulrahman AlkandariRan2026 to 2028Enrolled24ConditionsCOPD, COPD (Chronic Obstructive Pulmonary Disease), Cognitive Impairment (CI), Non-invasive Brain StimulationArmsNon-invasive brain stimulation, Sham Non-Invasive brain stimulation
3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  8. Serum Albumin Level at Intensive Care Unit Admission and Delirium Duration and Severity in Critically Ill Adults.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2024
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  16. The burden of cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cutter A LindberghDepartment of Psychology, University of Georgia, Athens, GA, 30602, USA. cal@uga.edu.
Rodney K DishmanDepartment of Kinesiology, University of Georgia, Athens, GA, 30602, USA.
L Stephen MillerDepartment of Psychology, University of Georgia, Athens, GA, 30602, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating evidence suggests that the pre-dementia syndrome mild cognitive impairment (MCI) is characterized by decrements in instrumental activities of daily living (IADL). The current review was a quantitative synthesis of the available literature to objectively characterize IADL disability in MCI while clarifying inconsistencies in findings across studies. It was hypothesized that individuals with MCI would display significantly greater functional impairment relative to cognitively intact controls. Candidate moderators specified a priori included functional assessment approach, MCI subtype, depressive symptoms, and language conducted. Online databases (PubMed/MEDLINE and PsycINFO) and reference lists were searched to identify peer-reviewed publications assessing IADL in MCI compared to normal aging. A total of 151 effect sizes derived from 106 studies met inclusionary criteria (N = 62,260). Random effects models yielded a large overall summary effect size (Hedges' g = 0.76, 95 % confidence interval: 0.68 - 0.83, p < .001) confirmed in multi-level analyses adjusted for nesting of effect sizes within studies (g = 0.78, 95 % confidence interval: 0.69 - 0.87). Functional assessment strategy and MCI subtype were significant moderators of effect size, whereas depressive symptoms and language were not. Results convincingly demonstrate that MCI is associated with significant difficulties in the performance of complex everyday tasks. It appears that functional decline, like cognitive decline, exists on a continuum from healthy aging to dementia onset. Implications for clinical practice and research priorities are discussed.

Indexed as

Activities of Daily LivingCognitive DysfunctionDepressionHumansLanguageActivities of daily livingAgingFunctional abilityMild cognitive impairment

Identifiers

PMID27393566

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.