Evidence map›Paper›PMID 27393339›Full record

ArticleJournal of neuroinflammation2016

Circulating microRNAs as biomarkers for rituximab therapy, in neuromyelitis optica (NMO).

Adi Vaknin-Dembinsky, Hanna Charbit, Livnat Brill, Oded Abramsky, Devorah Gur-Wahnon, Iddo Z Ben-Dov, Iris Lavon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 33 citations in OpenAlex.

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  8. Identifying the culprits in neurological autoimmune diseases.Journal of translational autoimmunity · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Adi Vaknin-DembinskyDepartment of Neurology, Multiple Sclerosis Center and Laboratory of Neuroimmunology, and the Agnes-Ginges Center for Neurogenetics, Hadassah Hebrew University Medical Center, Ein-Karem, Jerusalem, 91120, Israel. adembinsky@gmail.com.
Hanna CharbitDepartment of Neurology, Multiple Sclerosis Center and Laboratory of Neuroimmunology, and the Agnes-Ginges Center for Neurogenetics, Hadassah Hebrew University Medical Center, Ein-Karem, Jerusalem, 91120, Israel.
Livnat BrillDepartment of Neurology, Multiple Sclerosis Center and Laboratory of Neuroimmunology, and the Agnes-Ginges Center for Neurogenetics, Hadassah Hebrew University Medical Center, Ein-Karem, Jerusalem, 91120, Israel.
Oded AbramskyDepartment of Neurology, Multiple Sclerosis Center and Laboratory of Neuroimmunology, and the Agnes-Ginges Center for Neurogenetics, Hadassah Hebrew University Medical Center, Ein-Karem, Jerusalem, 91120, Israel.
Devorah Gur-WahnonNephrology and Hypertension Services, Internal Medicine Wing, Hadassah Hebrew University Medical Center, Ein-Karem, Jerusalem, 91120, Israel.
Iddo Z Ben-DovNephrology and Hypertension Services, Internal Medicine Wing, Hadassah Hebrew University Medical Center, Ein-Karem, Jerusalem, 91120, Israel.
Iris LavonDepartment of Neurology, Multiple Sclerosis Center and Laboratory of Neuroimmunology, and the Agnes-Ginges Center for Neurogenetics, Hadassah Hebrew University Medical Center, Ein-Karem, Jerusalem, 91120, Israel.
Hadassah Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeuromyelitis optica (NMO) is a chronic autoimmune disease of the central nervous system (CNS). The main immunological feature of the disease is the presence of autoantibodies to Aquaporin 4 (AQP4+), identified in about 82 % of cases. Currently, there are no reliable biomarkers for monitoring treatment response in patients with NMO. In an effort to identify biomarkers, we analyzed microRNAs (miRNAs) in the blood of rituximab-treated NMO patients before and after therapy.

methodsTotal RNA extracted from whole blood of nine rituximab-responsive NMO patients before and 6 months following treatment was subjected to small RNAseq analysis. The study included an additional group of seven untreated AQP4+ seropositive NMO patients and 15 healthy controls (HCs).

resultsFourteen miRNAs were up regulated and 32 were downregulated significantly in the blood of NMO patients following effective therapy with rituximab (all p < 0.05). Furthermore, we show that expression of 17 miRNAs was significantly higher and of 25 miRNAs was significantly lower in untreated NMO patients compared with HCs (all p < 0.05). Following rituximab treatment, the expression levels of 10 of the 17 miRNAs that show increased expression in NMO reverted to the levels seen in HCs. Six of these "normalized" miRNAs are known as brain-specific/enriched miRNAs.

conclusionsSpecific miRNA signatures in whole blood of patients with NMO might serve as biomarkers for therapy response. Furthermore, monitoring the levels of brain-specific/enriched miRNAs in the blood might reflect the degree of disease activity in the CNS of inflammatory demyelinating disorders.

Indexed as

AdultBiomarkersCohort StudiesHumansImmunologic FactorsMagnetic Resonance ImagingMicroRNAsMiddle AgedNeuromyelitis OpticaRituximabBiomarkersImmunologic FactorsMicroRNAsRituximabAquaporin 4 (AQP4)Brain-specific microRNAsCirculating biomarkersNeuromyelitis optica (NMO)Rituximab

Identifiers

PMID27393339
PMCPMC4939003
OpenAlexW2475110200

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.