Evidence map›Paper›PMID 27393281›Full record

ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2016

Copy number variations and stroke.

Valeria Colaianni, Rosalucia Mazzei, Sebastiano Cavallaro

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The effect of different ankle and knee supports on balance in early ambulation of post-stroke hemiplegic patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017
    Trial
  3. Article
  4. Article
  5. Current genomics · 2018
    Article
  6. Factors influencing pre-stroke and post-stroke quality of life among stroke survivors in a lower middle-income country.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018
    Article
  7. Review
  8. Advances in clinical neurology through the journal "Neurological Sciences" (2015-2016).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Valeria ColaianniInstitute of Neurological Sciences, CNR, National Research Council, Loc.Burga, 87050, Mangone, CS, Italy.
Rosalucia MazzeiInstitute of Neurological Sciences, CNR, National Research Council, Loc.Burga, 87050, Mangone, CS, Italy. rosalucia.mazzei@cnr.it.ORCID http://orcid.org/0000-0001-6619-6075
Sebastiano CavallaroInstitute of Neurological Sciences, CNR, National Research Council, Loc.Burga, 87050, Mangone, CS, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke is the third leading cause of death worldwide after heart disease and all forms of cancers. Monogenic disorders, genetic, and environmental risk factors contribute to damaging cerebral blood vessels and, consequently, cause stroke. Developments in genomic research led to the discovery of numerous copy number variants (CNVs) that have been recently identified as a new tool for understanding the genetic basis of many diseases. This review discusses the current understanding of the types of stroke, the existing knowledge on the involvement of specific CNVs in stroke as well as the limitations of the methods used for detecting CNVs like SNP-microarray. To confirm an unequivocally association between CNVs and stroke and extend the current findings, it would be desirable to use another methodology to detect smaller CNVs or CNVs in genomic regions poorly covered by this technique, for instance, CGH-array.

Indexed as

Comparative Genomic HybridizationDNA Copy Number VariationsGenome, HumanGenotypeHumansOligonucleotide Array Sequence AnalysisPhenotypeStrokeComparative genome hybridization (CGH) arraysDNA copy number variantsSingle-nucleotide polymorphism (SNP) arraysStroke

Identifiers

PMID27393281
PMCPMC5110597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.