Evidence map›Paper›PMID 27393279›Full record

ArticleInternational journal of hematology2016

Low prognostic nutritional index predicts poor outcome in diffuse large B-cell lymphoma treated with R-CHOP.

Qinjun Zhou, Yongqiang Wei, Fen Huang, Xiaolei Wei, Qi Wei, Xiaoxiao Hao, Yuankun Zhang, Ru Feng

Abstract read
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In one paragraph

Article in International journal of hematology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Predictive value of prognostic nutritional index as prognostic biomarkers in patients with lymphoma: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qinjun ZhouDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou Dadao North Street No. 1838, Guangzhou, 510515, China.
Yongqiang WeiDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou Dadao North Street No. 1838, Guangzhou, 510515, China.
Fen HuangDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou Dadao North Street No. 1838, Guangzhou, 510515, China.
Xiaolei WeiDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou Dadao North Street No. 1838, Guangzhou, 510515, China.
Qi WeiDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou Dadao North Street No. 1838, Guangzhou, 510515, China.
Xiaoxiao HaoDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou Dadao North Street No. 1838, Guangzhou, 510515, China.
Yuankun ZhangDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou Dadao North Street No. 1838, Guangzhou, 510515, China.
Ru FengDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou Dadao North Street No. 1838, Guangzhou, 510515, China. ruth1626@hotmail.com.
Nanfang Hospital · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prognostic nutritional index (PNI), based on serum albumin concentration and the absolute peripheral lymphocyte count, has been used to predict survival in various tumors. Whether PNI can predict prognosis in patients with diffuse large B-cell lymphoma (DLBCL) remains unknown. We retrospectively analyzed 253 patients with newly diagnosed DLBCL in the present study. The PNI was calculated as: albumin (g/L) + 5 × total lymphocyte count × 10(9)/L. All patients were divided in low and high groups according to the analysis of receiver operating characteristic (ROC) curve. Low PNI was associated with more unfavorable clinical features (p < 0.05). Patients with low PNI tended to have worse event-free survival (EFS) and overall survival (OS) (EFS, p = 0.001; OS, p < 0.001). For patients treated with R-CHOP, PNI proved to be predictive for survival (EFS, p = 0.001; OS, p < 0.001), while no significant effect was found in DLBCL patients who received CHOP chemotherapy (EFS, p = 0.496; OS, p = 0.125). Multivariate analysis showed that low PNI is an independent adverse predictor of OS and EFS, especially in DLBCL patients treated with R-CHOP. In conclusion, this study suggests that PNI is an effective prognostic factor in DLBCL patients treated with R-CHOP.

Indexed as

Nutrition AssessmentAntibodies, Monoclonal, Murine-DerivedAntineoplastic Combined Chemotherapy ProtocolsCyclophosphamideDoxorubicinHumansLymphocyte CountLymphoma, Large B-Cell, DiffusePrednisonePrognosisRetrospective StudiesRituximabSerum AlbuminSurvival RateVincristineAntibodies, Monoclonal, Murine-DerivedCyclophosphamideDoxorubicinPrednisoneR-CHOP protocolRituximabSerum AlbuminVincristineDiffuse large B-cell lymphomaPrognosisPrognostic nutritional index

Identifiers

PMID27393279
OpenAlexW2474287722

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.