Evidence map›Paper›PMID 27393011›Full record

ArticleBMC infectious diseases2016

Serotype influences on dengue severity: a cross-sectional study on 485 confirmed dengue cases in Vitória, Brazil.

Creuza Rachel Vicente, Karl-Heinz Herbinger, Günter Fröschl, Camila Malta Romano, Aline de Souza Areias Cabidelle, Crispim Cerutti Junior

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06697041 (Clinical and Laboratory Factors for the Progression of Severe Dengue Among Hospitalized Patients During an Upsurge), which is not on this map. Cited by 72 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06697041 completednot on this mapstarted 2024, after this paper: background citation

Clinical and Laboratory Factors for the Progression of Severe Dengue Among Hospitalized Patients During an Upsurge

TypeobservationalSponsorInternational Centre for Diarrhoeal Disease Research, BangladeshRan2024 to 2024Enrolled324ConditionsDengue Fever With Warning Signs
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Creuza Rachel VicenteCenter for International Health, Medical Center of the University of Munich, Leopoldstraße 7, 80802, Munich, Germany. Rachel.Vicente@lrz.uni-muenchen.de.
Karl-Heinz HerbingerDepartment of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich, Leopoldstraße 5, 80802, Munich, Germany.
Günter FröschlCenter for International Health, Medical Center of the University of Munich, Leopoldstraße 7, 80802, Munich, Germany.
Camila Malta RomanoInstitute of Tropical Medicine, University of São Paulo, Avenida Eneas de Carvalho Aguiar 470, 05403-000, São Paulo, Brazil.
Aline de Souza Areias CabidelleCoordination of Epidemiological Surveillance, Health Department of Vitória, Avenida Marechal Mascarenhas de Moraes 1185, 29017-010, Vitória, Brazil.
Crispim Cerutti JuniorDepartment of Social Medicine, Federal University of Espírito Santo, Avenida Marechal Campos 1468, 29040-090, Vitória, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDengue is caused by a RNA virus of the family Flaviviridae, which presents four serotypes (DENV-1 to DENV-4) capable of inducing hemorrhage. The purpose of this study was to evaluate the influence of serotype on the outcome of dengue.

methodsThis cross-sectional study included data from dengue cases with serotyping results that occurred between 2009 and 2013 in Vitória, Espírito Santo, Brazil. Data were accessed through the Information System for Notifiable Diseases. Chi-square test, Fisher exact test, Mann-Whitney U test, and logistic regression were performed to assess associations between different serotypes and dengue severity, while considering gender and age.

resultsThe sample consisted of 485 laboratory confirmed dengue cases, of which 46.4 % were females, with median age of 26 years. Regarding overall samples, 77.3 % were caused by DENV-1, 16.1 % by DENV-4, 6.4 % by DENV-2, and 0.2 % by DENV-3. Severe dengue affected 6.6 % of all cases, of which 32.3 % of the cases caused by DENV-2, 6.4 % of those caused by DENV-4, 4.5 % of those caused by DENV-1, and none of those caused by DENV-3. Severe dengue was found to be seven times more frequent among cases of DENV-2 than among those of the other serotypes.

conclusionsThe present study found that cases of DENV-2 had a higher proportion of severe dengue than among those of DENV-1 and DENV-4. Consequently, early detection of serotypes circulating in the territory could be an important approach to prevent increasing numbers of severe outcomes during dengue outbreaks by predicting the health support needed for early diagnoses and treatment of dengue cases.

Indexed as

AdolescentAdultBrazilCross-Sectional StudiesDengueDengue VirusFemaleHumansLogistic ModelsMaleMiddle AgedSerogroupSerotypingSevere DengueSeverity of Illness IndexStatistics, NonparametricDengue virusSevere dengueSigns and symptoms

Identifiers

PMID27393011
PMCPMC4938938

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.