Evidence map›Paper›PMID 27392959›Full record

ArticleInternational journal of legal medicine2016

Early markers for myocardial ischemia and sudden cardiac death.

Sara Sabatasso, Patrice Mangin, Tony Fracasso, Milena Moretti, Mylène Docquier, Valentin Djonov

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Article in International journal of legal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sara SabatassoUniversity Center of Legal Medicine Lausanne-Geneva, Rue Michel-Servet 1, CH 1211, Geneva, Switzerland. sara.sabatasso@hcuge.ch.
Patrice ManginUniversity Center of Legal Medicine Lausanne-Geneva, Rue Michel-Servet 1, CH 1211, Geneva, Switzerland.
Tony FracassoUniversity Center of Legal Medicine Lausanne-Geneva, Rue Michel-Servet 1, CH 1211, Geneva, Switzerland.
Milena MorettiUniversity Center of Legal Medicine Lausanne-Geneva, Rue Michel-Servet 1, CH 1211, Geneva, Switzerland.
Mylène DocquierGenomics platform, Centre Médical Universitaire, University of Geneva, CH 1211, Geneva, Switzerland.
Valentin DjonovInstitute of Anatomy, University of Bern, CH 3000, Bern, Switzerland.
University Centre of Legal Medicine · CHUniversity of Bern · CHUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The post-mortem diagnosis of acute myocardial ischemia remains a challenge for both clinical and forensic pathologists. We performed an experimental study (ligation of left anterior descending coronary artery in rats) in order to identify early markers of myocardial ischemia, to further apply to forensic and clinical pathology in cases of sudden cardiac death. Using immunohistochemistry, Western blots, and gene expression analyses, we investigated a number of markers, selected among those which are currently used in emergency departments to diagnose myocardial infarction and those which are under investigation in basic research and autopsy pathology studies on cardiovascular diseases. The study was performed on 44 adult male Lewis rats, assigned to three experimental groups: control, sham-operated, and operated. The durations of ischemia ranged between 5 min and 24 h. The investigated markers were troponins I and T, myoglobin, fibronectin, C5b-9, connexin 43 (dephosphorylated), JunB, cytochrome c, and TUNEL staining. The earliest expressions (≤30 min) were observed for connexin 43, JunB, and cytochrome c, followed by fibronectin (≤1 h), myoglobin (≤1 h), troponins I and T (≤1 h), TUNEL (≤1 h), and C5b-9 (≤2 h). By this investigation, we identified a panel of true early markers of myocardial ischemia and delineated their temporal evolution in expression by employing new technologies for gene expression analysis, in addition to traditional and routine methods (such as histology and immunohistochemistry). Moreover, for the first time in the autopsy pathology field, we identified, by immunohistochemistry, two very early markers of myocardial ischemia: dephosphorylated connexin 43 and JunB.

Indexed as

Death, Sudden, CardiacAnimalsAntibodiesBiomarkersComplement Membrane Attack ComplexConnexin 43Cytochromes cFibronectinsForensic PathologyImmunohistochemistryMaleModels, AnimalMyocardial IschemiaMyoglobinRats, Inbred LewTranscription FactorsAntibodiesBiomarkersComplement Membrane Attack ComplexConnexin 43Cytochromes cFibronectinsJunB protein, mouseMyoglobinTranscription FactorsTroponin ITroponin TClinical pathologyEarly markersForensic pathologyMyocardial ischemiaSudden cardiac death

Identifiers

PMID27392959
OpenAlexW2472646854

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.