ArticleJournal of Alzheimer's disease : JAD2016
Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimer's Disease Pathology.
Article in Journal of Alzheimer's disease : JAD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Visceral adipose tissue differentially affects tau and Aβ pathology in 3xTg-AD mice.Cell communication and signaling : CCS · 2026Article
- Elevated blood glucose levels are associated with the progression of brain hypometabolism, and HDL-C andmedRxiv : the preprint server for health sciences · 2024Article
- Associations of sugar intake, high-sugar dietary pattern, and the risk of dementia: a prospective cohort study of 210,832 participants.BMC medicine · 2024Article
- Life course plasma metabolomic signatures of genetic liability to Alzheimer's disease.Scientific reports · 2024Article
- Type 2 Diabetes Moderates the Association Between Amyloid and 1-Year Change in Everyday Functioning in Older Veterans.Journal of Alzheimer's disease : JAD · 2024Article
- APOE and immunity: Research highlights.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Review
- Review
- Intrusion errors moderate the relationship between blood glucose and regional cerebral blood flow in cognitively unimpaired older adults.Brain imaging and behavior · 2022Article
- Arterial stiffening acts synergistically with APOE genotype and AD biomarker status to influence memory in older adults without dementia.Alzheimer's research & therapy · 2021Article
- Plasma Apolipoprotein E3 and Glucose Levels Are Associated in APOE ɛ3/ɛ4 Carriers.Journal of Alzheimer's disease : JAD · 2021Article
- Prediabetes Is Associated With Brain Hypometabolism and Cognitive Decline in a Sex-Dependent Manner: A Longitudinal Study of Nondemented Older Adults.Frontiers in neurology · 2021Article
- High Glycemic Load Is Associated with Cognitive Decline in Apolipoprotein E ε4 Allele Carriers.Nutrients · 2020Article
- Oxidized cholesterol species as signaling molecules in the brain: diabetes and Alzheimer's disease.Neuronal signaling · 2019Review
- Cognitive resilience among APOE ε4 carriers in the oldest old.International journal of geriatric psychiatry · 2019Article
- The role of APOE4 in Alzheimer's disease: strategies for future therapeutic interventions.Neuronal signaling · 2019Review
- Neuropsychological Criteria for Mild Cognitive Impairment in the Framingham Heart Study's Old-Old.Dementia and geriatric cognitive disorders · 2018Article
- Reduced Regional Cerebral Blood Flow Relates to Poorer Cognition in Older Adults With Type 2 Diabetes.Frontiers in aging neuroscience · 2018Article
- A cross-sectional study of inpatients with late stage of dementia in Southeast China and the associations between biochemical parameters and apolipoprotein E genotypes.Clinical interventions in aging · 2018Article
- Type 2 Diabetes Interacts With Alzheimer Disease Risk Factors to Predict Functional Decline.Alzheimer disease and associated disordersArticle
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Elevated blood glucose and the apolipoprotein (APOE) ɛ4 allele have both been associated with increased dementia risk; however, the neuropathological mechanisms underlying these associations remain unclear. We examined the impact of APOE genotype and midlife blood glucose on post-mortem vascular and Alzheimer's disease (AD) neuropathology. Ninety-four participants from the Framingham Heart Study without diagnosed diabetes underwent health examination at midlife and brain autopsy at death. Histopathological measures of vascular and AD neuropathology were obtained and analyzed. Results demonstrated that, among APOE ɛ4 carriers, elevated blood glucose was associated with more severe AD pathology. There was no such relationship with vascular pathology. In a relatively healthy sample with low vascular risk burden, midlife elevated blood glucose was associated with greater AD pathology among APOE ɛ4 carriers. A better understanding of interactive effects of APOE genotype and vascular risk on neuropathology has implications for identification of individuals at risk for decline and long-term preventive treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.