ArticleBrain imaging and behavior2017
Gray matter volume and dual-task gait performance in mild cognitive impairment.
Article in Brain imaging and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Relationship Between Cognitive Abilities and Lower-Limb Movements: Can Analyzing Gait Parameters and Movements Help Detect Dementia? A Systematic Review.Sensors (Basel, Switzerland) · 2025Pooled it
- Gait in cerebral small vessel disease, pre-dementia, and dementia: A systematic review.International journal of stroke : official journal of the International Stroke Society · 2023Pooled it
- Neural Mechanisms of Motor Dysfunction in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review.Journal of Alzheimer's disease reports · 2022Pooled it
- Gait Speed and Evolution of Verbal Fluencies in Frail or Prefrail Older People with Type 2 Diabetes. A Pilot Study.The journal of nutrition, health & aging · 2021Trial
- Sex-specific brain atrophy patterns associated with the motoric cognitive risk syndrome.Journal of Alzheimer's disease : JAD · 2025Article
- Grey matter atrophy patterns of mobility shared across older adults with and without multiple sclerosis.Journal of neurology · 2025Article
- Mapping the neural substrate of high dual-task gait cost in older adults across the cognitive spectrum.Brain structure & function · 2025Article
- Talking during walking: the diagnostic potential of turn dynamics in Alzheimer's disease, mild cognitive impairment and cognitive aging.Frontiers in aging neuroscience · 2025Article
- Gait analysis in older adults with mild cognitive impairment: a bibliometric analysis of global trends, hotspots, and emerging frontiers.Frontiers in aging · 2025Article
- Distinctive Gait Variations and Neuroimaging Correlates in Alzheimer's Disease and Cerebral Small Vessel Disease.Journal of cachexia, sarcopenia and muscle · 2024Article
- Impact of distinct cognitive domains on gait variability in individuals with mild cognitive impairment and dementia.Experimental brain research · 2024Article
- Investigating underlying brain structures and influence of mild and subjective cognitive impairment on dual-task performance in people with Parkinson's disease.Scientific reports · 2024Article
- Bradykinesia and rigidity modulated by functional connectivity between the primary motor cortex and globus pallidus in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- Cortical thickness is related to cognitive-motor automaticity and attention allocation in individuals with Alzheimer's disease: a regions of interest study.Experimental brain research · 2023Article
- Association between P300 parameters and cognitive function in people with diabetic neuropathy.Journal of diabetes and metabolic disorders · 2023Article
- Turning and multitask gait unmask gait disturbance in mild-to-moderate multiple sclerosis: Underlying specific cortical thinning and connecting fibers damage.Human brain mapping · 2023Article
- Visual Occlusions Result in Phase Synchrony Within Multiple Brain Regions Involved in Sensory Processing and Balance Control.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2023Article
- A Review of the Measurement of the Neurology of Gait in Cognitive Dysfunction or Dementia, Focusing on the Application of fNIRS during Dual-Task Gait Assessment.Brain sciences · 2022Review
- Associations between gait speed and brain structure in amnestic mild cognitive impairment: a quantitative neuroimaging study.Brain imaging and behavior · 2022Article
- Effects of Exergaming-Based Tai Chi on Cognitive Function and Dual-Task Gait Performance in Older Adults With Mild Cognitive Impairment: A Randomized Control Trial.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Dual-task gait performance is impaired in older adults with mild cognitive impairment, but the brain substrates associated with dual-task gait performance are not well-established. The relationship between gray matter and gait speed under single-task and dual-task conditions (walking while counting backward) was examined in 560 seniors with mild cognitive impairment (non-amnestic mild cognitive impairment: n = 270; mean age = 72.4 yrs., 63.6 % women; amnestic mild cognitive impairment: n = 290; mean age = 73.4 yrs., 45.4 % women). Multivariate covariance-based analyses of magnetic resonance imaging data, adjusted for potential confounders including single-task gait speed, were performed to identify gray matter patterns associated with dual-task gait speed. There were no differences in gait speed or cognitive performance during dual-task gait between individuals with non-amnestic mild cognitive impairment and amnestic mild cognitive impairment. Overall, increased dual-task gait speed was associated with a gray matter pattern of increased volume in medial frontal gyrus, superior frontal gyrus, anterior cingulate, cingulate, precuneus, fusiform gyrus, middle occipital gyrus, inferior temporal gyrus and middle temporal gyrus. The relationship between dual-task gait speed and brain substrates also differed by mild cognitive impairment subtype. Our study revealed a pattern of gray matter regions associated with dual-task performance. Although dual-task gait performance was similar in amnestic and non-amnestic mild cognitive impairment, the gray matter patterns associated with dual-task gait performance differed by mild cognitive impairment subtype. These findings suggest that the brain substrates supporting dual-task gait performance in amnestic and non-amnestic subtypes are different, and consequently may respond differently to interventions, or require different interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.