ReviewHeart failure reviews2017
Peripheral vascular function, oxygen delivery and utilization: the impact of oxidative stress in aging and heart failure with reduced ejection fraction.
Review in Heart failure reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02209610 (Premature Fatigue in Veterans With Heart Failure), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Premature Fatigue in Veterans With Heart Failure: Neuronal Influences
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Lower vascular conductance responses to handgrip exercise are improved following acute antioxidant supplementation in young individuals with post-traumatic stress disorder.Experimental physiology · 2024Trial
- Dietary Nitrate Increases VOJournal of cardiac failure · 2018Trial
- Oxidative stress and impaired cardiovagal baroreflex sensitivity in young adults with post-traumatic stress disorder.Experimental physiology · 2026Article
- Probiotics intervention reduces oxidative stress-driven myocardial injury.Scientific reports · 2025Article
- Multiple Organ Phenotype of Fatigue.Biomolecules · 2025Review
- The inorganic NItrate and eXercise performance in Heart Failure (iNIX-HF) phase II clinical trial: Rationale and study design.Contemporary clinical trials communications · 2023Article
- Sacubitril/valsartan protects against arsenic trioxide induced cardiotoxicity in vivo and in vitro.Toxicology research · 2022Article
- Contrast Ultrasound Assessment of Skeletal Muscle Recruitable Perfusion after Permanent Left Ventricular Assist Device Implantation: Implications for Functional Recovery.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2022Article
- Chronic Kidney Disease Increases Risk of Incident HFrEF Following Percutaneous Coronary Intervention.Frontiers in cardiovascular medicine · 2022Article
- Locomotor Muscle Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Sacubitril-valsartan improves conduit vessel function and functional capacity and reduces inflammation in heart failure with reduced ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Cardiac Aging: From Basic Research to Therapeutics.Oxidative medicine and cellular longevity · 2021Review
- Is Willebrand Factor Indicative of Chronic Inflammation in Children with Asthma?Turkish thoracic journal · 2020Article
- Chronic antioxidant administration restores macrovascular function in patients with heart failure with reduced ejection fraction.Experimental physiology · 2020Article
- Impacts of prolonged sitting with mild hypercapnia on vascular and autonomic function in healthy recreationally active adults.American journal of physiology. Heart and circulatory physiology · 2020Article
- Serum Tumor Necrosis Factor-alpha associates with Myocardial Oxygen Demand and Exercise Tolerance in Postmenopausal Women.International journal of exercise science · 2018Article
- Redox theory of aging: implications for health and disease.Clinical science (London, England : 1979) · 2017Review
- The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine.Mediators of inflammation · 2017Review
- Advanced Maternal Age Worsens Postpartum Vascular Function.Frontiers in physiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The aging process appears to be a precursor to many age-related diseases, perhaps the most impactful of which is cardiovascular disease (CVD). Heart disease, a manifestation of CVD, is the leading cause of death in the USA, and heart failure (HF), a syndrome that develops as a consequence of heart disease, now affects almost six million American. Importantly, as this is an age-related disease, this number is likely to grow along with the ever-increasing elderly population. Hallmarks of the aging process and HF patients with a reduced ejection fraction (HFrEF) include exercise intolerance, premature fatigue, and limited oxygen delivery and utilization, perhaps as a consequence of diminished peripheral vascular function. Free radicals and oxidative stress have been implicated in this peripheral vascular dysfunction, as a redox imbalance may directly impact the function of the vascular endothelium. This review aims to bring together studies that have examined the impact of oxidative stress on peripheral vascular function and oxygen delivery and utilization with both healthy aging and HFrEF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.