Evidence map›Paper›PMID 27392645›Full record

ArticleJournal of biomedical informatics2016

Developing a data element repository to support EHR-driven phenotype algorithm authoring and execution.

Guoqian Jiang, Richard C Kiefer, Luke V Rasmussen, Harold R Solbrig, Huan Mo, Jennifer A Pacheco, Jie Xu, Enid Montague, William K Thompson, Joshua C Denny and 2 more

Abstract read
In one paragraph

Article in Journal of biomedical informatics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Common data elements for food allergy clinical trials: an overview.Current opinion in allergy and clinical immunology · 2025
    Review
  3. HL7 FHIR-based tools and initiatives to support clinical research: a scoping review.Journal of the American Medical Informatics Association : JAMIA · 2022
    Article
  4. Article
  5. Article
  6. UK phenomics platform for developing and validating electronic health record phenotypes: CALIBER.Journal of the American Medical Informatics Association : JAMIA · 2019
    Article
  7. Unleashing the value of Common Data Elements through the CEDAR Workbench.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2019
    Article
  8. Defining Phenotypes from Clinical Data to Drive Genomic Research.Annual review of biomedical data science · 2018
    Article
  9. Clinical Research Informatics: Contributions from 2016.Yearbook of medical informatics · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Guoqian JiangDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA. Electronic address: Jiang.Guoqian@mayo.edu.
Richard C KieferDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA.
Luke V RasmussenDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Harold R SolbrigDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA.
Huan MoDepartment of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA.
Jennifer A PachecoCenter for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Jie XuFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Enid MontagueFeinberg School of Medicine, Northwestern University, Chicago, IL, USA; School of Computing, DePaul University, Chicago, IL, USA.
William K ThompsonSchool of Computing, DePaul University, Chicago, IL, USA.
Joshua C DennyDepartment of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA; Department of Medicine, Vanderbilt University, Nashville, TN, USA.
Christopher G ChuteSchool of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Jyotishman PathakDivision of Health Informatics, Weill Cornell Medical College, Cornell University, New York City, NY, USA.

Funding

Genomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5M
National Infrastructure for Standardized and Portable EHR Phenotyping AlgorithmsR01GM105688 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI LUO, YUAN, PATHAK, JYOTISHMAN · 2013 to 2020
$5.7M
A Personalized Genomic Medicine Pilot Program Using the NJgene eMERGE ExperienceU01HG006388 · NHGRI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHISHOLM, REX L, SMITH, MAUREEN E · 2011 to 2014
$4.1M
Genomic Medicine at Northwestern: Discovery and ImplementationU01HG008673 · NHGRI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHISHOLM, REX L, SMITH, MAUREEN E · 2015 to 2019
$4.1M
Vanderbilt Genome Electronic Records ProjectU01HG006378 · NHGRI · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2011 to 2014
$4.0M
Informatics Tools for Pharmacogenomic Discovery using Practice-based DataR01GM103859 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENNY, JOSHUA C., PATHAK, JYOTISHMAN · 2014 to 2017
$2.4M
caCDE-QA: A Quality Assurance Platform for Cancer Study Common Data ElementsU01CA180940 · NCI · MAYO CLINIC ROCHESTER · PI JIANG, GUOQIAN · 2014 to 2016
$1.1M
NCI NIH HHS U01 CA180940NHGRI NIH HHS U01 HG006378NHGRI NIH HHS U01 HG006379NHGRI NIH HHS U01 HG006388NHGRI NIH HHS U01 HG008673NIGMS NIH HHS R01 GM103859NIGMS NIH HHS R01 GM105688
6 · The paper itself

Abstract

The Quality Data Model (QDM) is an information model developed by the National Quality Forum for representing electronic health record (EHR)-based electronic clinical quality measures (eCQMs). In conjunction with the HL7 Health Quality Measures Format (HQMF), QDM contains core elements that make it a promising model for representing EHR-driven phenotype algorithms for clinical research. However, the current QDM specification is available only as descriptive documents suitable for human readability and interpretation, but not for machine consumption. The objective of the present study is to develop and evaluate a data element repository (DER) for providing machine-readable QDM data element service APIs to support phenotype algorithm authoring and execution. We used the ISO/IEC 11179 metadata standard to capture the structure for each data element, and leverage Semantic Web technologies to facilitate semantic representation of these metadata. We observed there are a number of underspecified areas in the QDM, including the lack of model constraints and pre-defined value sets. We propose a harmonization with the models developed in HL7 Fast Healthcare Interoperability Resources (FHIR) and Clinical Information Modeling Initiatives (CIMI) to enhance the QDM specification and enable the extensibility and better coverage of the DER. We also compared the DER with the existing QDM implementation utilized within the Measure Authoring Tool (MAT) to demonstrate the scalability and extensibility of our DER-based approach.

Indexed as

AlgorithmsElectronic Health RecordsPhenotypeBiomedical ResearchDatabases, FactualHumansSemanticsHL7 Fast Healthcare Interoperability Resources (FHIR)Metadata standardsPhenotype algorithmsQuality Data Model (QDM)Semantic Web technology

Identifiers

PMID27392645
PMCPMC5490836

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.