ArticleBehavioural brain research2016
Forelimb training drives transient map reorganization in ipsilateral motor cortex.
Article in Behavioural brain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The ipsilateral corticospinal responses to cross-education are dependent upon the motor-training intervention.Experimental brain research · 2018Trial
- Micro-ultrasound based characterization of cerebrovasculature following focal ischemic stroke and upon short-term rehabilitation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Improvement of upper limb function in post-stroke patients with motion feedback training-based combination therapy: a retrospective analysis of muscle activation and recovery dynamics.American journal of translational research · 2024Article
- Quantitative Fluorescence Analysis Reveals Dendrite-Specific Thalamocortical Plasticity in L5 Pyramidal Neurons during Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Common Cholinergic, Noradrenergic, and Serotonergic Drugs Do Not Block VNS-Mediated Plasticity.Frontiers in neuroscience · 2022Article
- High intensity VNS disrupts VNS-mediated plasticity in motor cortex.Brain research · 2021Article
- A limited range of vagus nerve stimulation intensities produce motor cortex reorganization when delivered during training.Behavioural brain research · 2020Article
- Functional plasticity of the ipsilateral primary sensorimotor cortex in an elite long jumper with below-knee amputation.NeuroImage. Clinical · 2019Article
- Use-Dependent Plasticity in Human Primary Motor Hand Area: Synergistic Interplay Between Training and Immobilization.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Compensatory Relearning Following Stroke: Cellular and Plasticity Mechanisms in Rodents.Frontiers in neuroscience · 2018Review
- Expansion and Renormalization of Human Brain Structure During Skill Acquisition.Trends in cognitive sciences · 2017Review
- Traumatic Brain Injury Occludes Training-Dependent Cortical Reorganization in the Contralesional Hemisphere.Journal of neurotrauma · 2017Article
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Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Skilled motor training results in reorganization of contralateral motor cortex movement representations. The ipsilateral motor cortex is believed to play a role in skilled motor control, but little is known about how training influences reorganization of ipsilateral motor representations of the trained limb. To determine whether training results in reorganization of ipsilateral motor cortex maps, rats were trained to perform the isometric pull task, an automated motor task that requires skilled forelimb use. After either 3 or 6 months of training, intracortical microstimulation (ICMS) mapping was performed to document motor representations of the trained forelimb in the hemisphere ipsilateral to that limb. Motor training for 3 months resulted in a robust expansion of right forelimb representation in the right motor cortex, demonstrating that skilled motor training drives map plasticity ipsilateral to the trained limb. After 6 months of training, the right forelimb representation in the right motor cortex was significantly smaller than the representation observed in rats trained for 3 months and similar to untrained controls, consistent with a normalization of motor cortex maps. Forelimb map area was not correlated with performance on the trained task, suggesting that task performance is maintained despite normalization of cortical maps. This study provides new insights into how the ipsilateral cortex changes in response to skilled learning and may inform rehabilitative strategies to enhance cortical plasticity to support recovery after brain injury.
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