ArticlePediatric surgery international2016
Nuclear transit study in children with chronic faecal soiling after Hirschsprung disease (HSCR) surgery has revealed a group with rapid proximal colonic treatment and possible adverse reactions to food.
Article in Pediatric surgery international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Thirty years of paediatric colonic motility assessment modalities: a systematic review.Frontiers in pediatrics · 2026Pooled it
- Growth and dietary effects on gastrointestinal symptoms in children with Hirschsprung's disease.Pediatric surgery international · 2026Observational
- Influence of Diet on Bowel Function and Abdominal Symptoms in Children and Adolescents with Hirschsprung Disease-A Multinational Patient-Reported Outcome Survey.Children (Basel, Switzerland) · 2024Article
- The early years: hirschsprung disease and health-related quality of life.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Children with Hirschsprung's Disease Report Dietary Effects on Gastrointestinal Complaints More Frequently than Controls.Children (Basel, Switzerland) · 2023Article
- Diet and bowel function in children with Hirschsprung's disease: development and content validation of a patient-reported questionnaire.BMC nutrition · 2023Article
- Letter to the Editor regarding: Guidelines for the management of postoperative soiling in children with Hirschsprung disease, Saadai et al. PSI (2019)35: 829-834.Pediatric surgery international · 2020Article
- 'Rapid transit' constipation in children: a possible genesis for irritable bowel syndrome.Pediatric surgery international · 2020Review
- Dietary exclusion of fructose and lactose after positive breath tests improved rapid-transit constipation in children.JGH open : an open access journal of gastroenterology and hepatology · 2018Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background/purposeLong-term problems with faecal incontinence occur in up to 50 % of patients after pull-through for Hirschsprung disease (HSCR). The cause often remains unknown, leading to empirical treatments. Using nuclear transit study, we found some patients surprisingly had rapid proximal colonic transit, suspicious of occult diarrhoea. We aimed to assess whether these patients had unrecognized adverse reactions to food.
methodsPatients (n = 10, all males, 9.6 year; 4.25-15.5 years) with persistent faecal incontinence following pull-through for HSCR referred to the senior author and after exclusion of anatomical defects, underwent nuclear transit studies. Most (8) subsequently underwent breath hydrogen tests for sugar malabsorption and were tested for adverse reactions to food. Exclusion diets for protein allergens, lactose or fructose were then trialed.
resultsOf the 10 patients with rapid intestinal transit proven on nuclear transit study, breath hydrogen tests for fructose and/or lactose malabsorption were done in 8, and were positive in 7/8 patients. Exclusion diets contributed to either resolution or improvement in faecal incontinence in 9/10 patients.
conclusionsRapid transit in the proximal, ganglionated colon may be present in children with faecal incontinence following pull-through for HSCR, possibly secondary to adverse reactions to food. This study suggests that children with post-operative soiling may benefit from a transit study and hydrogen breath tests to diagnose adverse reactions to food caused by sugar malabsorption.
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