ArticleEnvironmental science and pollution research international2016
The effects of PM10 on electrocardiogram parameters, blood pressure and oxidative stress in healthy rats: the protective effects of vanillic acid.
Article in Environmental science and pollution research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- Preventive Effects of Vanillic Acid Against Lung Inflammation and Oxidative Stress Induced by Dust Particles in Wistar Rats.Journal of cellular and molecular medicine · 2025Article
- Anti-tumor role and molecular mechanism of vanillic acid.Discover oncology · 2025Review
- PMToxicology and applied pharmacology · 2024Article
- Anthocyanin Effects on Vascular and Endothelial Health: Evidence from Clinical Trials and Role of Gut Microbiota Metabolites.Antioxidants (Basel, Switzerland) · 2023Review
- Effect of long-term exposure to PMEnvironmental geochemistry and health · 2021Article
- Influence of the meteorological conditions and some pollutants on PMJournal of environmental health science & engineering · 2021Article
- Temporal fluctuations of PMJournal of environmental health science & engineering · 2020Article
- Investigation of fungal contamination in indoor air and on surfaces of traditional public baths in a historical city.Journal of environmental health science & engineering · 2020Article
- Safety Assessment of Vanillic Acid: Subacute Oral Toxicity Studies in Wistar Rats.Turkish journal of pharmaceutical sciences · 2020Article
- Ellagic Acid Ameliorates Lung Inflammation and Heart Oxidative Stress in Elastase-Induced Emphysema Model in Rat.Inflammation · 2020Article
- Estimation of hospital admission respiratory disease cases attributed to exposure to SOAfrican health sciences · 2019Article
- Inhale, exhale: Why particulate matter exposure in animal models are so acute? Data and facts behind the history.Data in brief · 2019Article
- Short-term effects of ambient air pollution and cardiovascular events in Shiraz, Iran, 2009 to 2015.Environmental science and pollution research international · 2019Article
- Effects of PMSaudi journal of biological sciences · 2019Article
- The Association between Indoor Air Quality and Adult Blood Pressure Levels in a High-Income Setting.International journal of environmental research and public health · 2018Article
- Association between cancer risk and polycyclic aromatic hydrocarbons' exposure in the ambient air of Ahvaz, southwest of Iran.International journal of biometeorology · 2018Article
- Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon.Particle and fibre toxicology · 2017Article
- Health benefits of PMInternational journal of biometeorology · 2017Article
- A comparative study of hospital admissions for respiratory diseases during normal and dusty days in Iran.Environmental science and pollution research international · 2017Article
- Comparison of normal and dusty day impacts on fractional exhaled nitric oxide and lung function in healthy children in Ahvaz, Iran.Environmental science and pollution research international · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Particulate matter (PM) inhalation is an established trigger of cardiovascular events such as cardiac arrhythmias that occur within hours to days after exposure. Higher daily PM levels are related to acute increases in systemic arterial blood pressure (BP). The aim of the present study was to evaluate the effects of PM10 on electrocardiogram (ECG) parameters, blood pressure, lipid peroxidation (MDA), xanthine oxidase, and antioxidant enzyme in healthy rats and also to examine the protective effects of vanillic acid (VA) in this respect. Eighty male Wistar rats were divided into eight groups (n = 10), namely control (normal saline, gavage), VAc (10 mg/kg), sham (normal saline, intratracheal instillation), VA (10 mg/kg VA, 10 days gavage +0.1 ml normal saline, intratracheal instillation), PM1 (0.5 mg/kg), PM2 (2.5 mg/kg), PM3 (5 mg/kg), PM3 + VA (5 mg/kg, intratracheal instillation + 10 mg/kg VA, 10 days, gavage) groups. The rats were anesthetized and 0.1 ml of saline as well as a certain concentration of PM10 was instilled into the trachea and it was repeated after 48 h, then 30 min after that, PR interval, QTc, and systolic blood pressure were measured. The activities of antioxidant enzymes, xanthine oxidase (XOX), and malondialdehyde (MDA) were measured in plasma by special Kits. A significant increase in blood pressure (BP), PR interval, QTc, MDA, and XOX and a significant decrease in antioxidant enzyme (CAT, SOD, and GPx) occurred in PM10 groups. Vanillic acid ameliorated blood pressure, QTc, PR interval, XOX, MDA, and increased antioxidant enzymes (SOD, CAT, and GPx) significantly. In the present study, it was shown that PM10 had devastating effects on the heart and blood pressure, probably due to the increased oxidative stress in healthy rats. Vanillic acid could improve the symptoms of PM10 exposure and can be used as an antioxidant agent against the harmful effects of PM10.
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