ReviewCellular and molecular life sciences : CMLS2016
Morphological and ultrastructural changes in bacterial cells as an indicator of antibacterial mechanism of action.
Review in Cellular and molecular life sciences : CMLS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
95 citing papers in PubMed.
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- Evaluation of Antimicrobial Activity of Gallic Acid, Quercetin-3-D-Glucuronide, and Apigenin Against Gram-Negative Uropathogens: A Novel Approach to Urinary Tract Infection Therapy.International journal of molecular sciences · 2026Article
- Exploring the Antimicrobial Potential of Vanadium-Based MXenes for Biomedical Applications.MicrobiologyOpen · 2026Article
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- UV-C LED wavelength effects on inactivation kinetics, DNA damage and membrane integrity in drinking water indicator bacteria.Scientific reports · 2026Article
- Functional Versatility of Sulfonamide-pyrazole Derivative: From Antibacterial Activity to Metal ion Sensing Aptitude.Journal of fluorescence · 2026Article
- SERS-Based Universal AST: Rapid Treatment Guidance for Blood-Culture Bacteria before Species Identification.Analytical chemistry · 2026Article
- Transforming Fragile Hydrogel Chips Into Standardized Cartridges via Contact Line Pinning for Robust Microfluidics.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Sahara Desert sand "Chitligsan": characterisation and assessment of antibacterial activity and cytotoxicity.RSC advances · 2026Article
- Article
- Thermal modulation of transcriptional states, biofilm architecture and survival strategies inFrontiers in microbiology · 2026Article
- Higher levels of antibiotic resistance are less competitive: the hidden ecological cost of no-metabolic cost resistance.bioRxiv : the preprint server for biology · 2025Article
- Deciphering the constraints of pure bacterial strains for the complete catabolism of sulfamethoxazole: A proteomic and kinetic study.Biodegradation · 2025Article
- 3D Bioprinted Engineered Living Microreactors for Continuous Organophosphorus Compound Degradation.Small science · 2025Article
- Metal-induced biofilm formation by radiation resistant bacteria Deinococcus radiodurans and Deinococcus indicus.Extremophiles : life under extreme conditions · 2025Article
- Article
- Effects of intravenous morphine and lidocaine on bacterial growth.BMC anesthesiology · 2025Article
- Monitoring phage infection and lysis of surface-immobilized bacteria by QCM-D.Analytical and bioanalytical chemistry · 2025Article
- Advancing antibiotic discovery with bacterial cytological profiling: a high-throughput solution to antimicrobial resistance.Frontiers in microbiology · 2025Review
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Efforts to reduce the global burden of bacterial disease and contend with escalating bacterial resistance are spurring innovation in antibacterial drug and biocide development and related technologies such as photodynamic therapy and photochemical disinfection. Elucidation of the mechanism of action of these new agents and processes can greatly facilitate their development, but it is a complex endeavour. One strategy that has been popular for many years, and which is garnering increasing interest due to recent technological advances in microscopy and a deeper understanding of the molecular events involved, is the examination of treated bacteria for changes to their morphology and ultrastructure. In this review, we take a critical look at this approach. Variables affecting antibacterial-induced alterations are discussed first. These include characteristics of the test organism (e.g. cell wall structure) and incubation conditions (e.g. growth medium osmolarity). The main body of the review then describes the different alterations that can occur. Micrographs depicting these alterations are presented, together with information on agents that induce the change, and the sequence of molecular events that lead to the change. We close by highlighting those morphological and ultrastructural changes which are consistently induced by agents sharing the same mechanism (e.g. spheroplast formation by peptidoglycan synthesis inhibitors) and explaining how changes that are induced by multiple antibacterial classes (e.g. filamentation by DNA synthesis inhibitors, FtsZ disruptors, and other types of agent) can still yield useful mechanistic information. Lastly, recommendations are made regarding future study design and execution.
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