ArticleAmerican journal of respiratory and critical care medicine2016
Early-Life Exposure to the Great Smog of 1952 and the Development of Asthma.
Article in American journal of respiratory and critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
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- Effect of In utero Exposure to Air Pollution on Adulthood Hospitalizations.Journal of urban health : bulletin of the New York Academy of Medicine · 2024Review
- Health Outcomes in Children Associated with Prenatal and Early-Life Exposures to Air Pollution: A Narrative Review.Toxics · 2022Review
- A review on factors influencing fog formation, classification, forecasting, detection and impacts.Rendiconti Lincei. Scienze fisiche e naturali · 2022Review
- Understanding the Pathways from Prenatal and Post-Birth PMInternational journal of environmental research and public health · 2021Observational
- Asthma: New Integrative Treatment Strategies for the Next Decades.Medicina (Kaunas, Lithuania) · 2020Review
- The Powerful Combination of Cross-country Comparisons and Life-History Data.Journal of the economics of ageing · 2020Article
- Longitudinal survey of microbiome associated with particulate matter in a megacity.Genome biology · 2020Article
- Air pollution-induced placental alterations: an interplay of oxidative stress, epigenetics, and the aging phenotype?Clinical epigenetics · 2019Review
- Preventing the development of asthma: stopping the allergic march.Current opinion in allergy and clinical immunology · 2019Review
- Impact of London's low emission zone on air quality and children's respiratory health: a sequential annual cross-sectional study.The Lancet. Public health · 2019Article
- In utero exposure to fine particulate matter results in an altered neuroimmune phenotype in adult mice.Environmental pollution (Barking, Essex : 1987) · 2018Article
- Air pollutants and early origins of respiratory diseases.Chronic diseases and translational medicine · 2018Article
- Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleLittle is known about the long-term effects of air pollution exposure and the root causes of asthma. We use exposure to intense air pollution from the 1952 Great Smog of London as a natural experiment to examine both issues.
objectivesTo determine whether exposure to extreme air pollution in utero or soon after birth affects asthma development later in life.
methodsThis was a natural experiment using the unanticipated pollution event by comparing the prevalence of asthma between those exposed to the Great Smog in utero or the first year of life with those conceived well before or after the incident and those residing outside the affected area at the time of the smog. MEASUREMENTS AND MAIN
resultsPrevalence of asthma during childhood (ages 0-15) and adulthood (ages >15) is analyzed for 2,916 respondents to the Life History portion of the English Longitudinal Study on Aging born from 1945 to 1955. Exposure to the Great Smog in the first year of life increases the likelihood of childhood asthma by 19.87 percentage points (95% confidence interval [CI], 3.37-36.38). We also find suggestive evidence that early-life exposure led to a 9.53 percentage point increase (95% CI, -4.85 to 23.91) in the likelihood of adult asthma and exposure in utero led to a 7.91 percentage point increase (95% CI, -2.39 to 18.20) in the likelihood of childhood asthma.
conclusionsThese results are the first to link early-life pollution exposure to later development of asthma using a natural experiment, suggesting the legacy of the Great Smog is ongoing.
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Registered trials
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