Trial reportPloS one2016
Spatial and Molecular Epidemiology of Giardia intestinalis Deep in the Amazon, Brazil.
Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Genotyping and epidemiological distribution of diarrhea-causing isolates of Giardia duodenalis in southeastern part of West Bengal, India.Parasitology research · 2023Article
- Zoonotic Giardia duodenalis assemblage A in northern sloth from Brazilian Amazon.Memorias do Instituto Oswaldo Cruz · 2023Article
- Genotypic and Epidemiologic Profiles of Giardia duodenalis in Four Brazilian Biogeographic RegionsMicroorganisms · 2022Article
- Spatio-temporal analysis and determination of the ecological niche model ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- A community-based, cross-sectional study to assess interactions between income, nutritional status and enteric parasitism in two Brazilian cities: are we moving positively towards 2030?Journal of health, population, and nutrition · 2021Article
- Epidemiology of Giardia duodenalis assemblages in Brazil: there is still a long way to go.Memorias do Instituto Oswaldo Cruz · 2021Review
- The Predominance of Giardia duodenalis AII sub-assemblage in young children from Salvador, Bahia, Brazil.Biomedica : revista del Instituto Nacional de Salud · 2020Article
- Article
- Genetic analysis of Giardia duodenalis isolates from children of low-income families living in an economically successful region in Southeastern Brazil.Revista do Instituto de Medicina Tropical de Sao Paulo · 2020Article
- Complex virome in feces from Amerindian children in isolated Amazonian villages.Nature communications · 2018Article
- Prevalence of intestinal parasites, with emphasis on the molecular epidemiology of Giardia duodenalis and Blastocystis sp., in the Paranaguá Bay, Brazil: a community survey.Parasites & vectors · 2018Article
- Assemblages A and B of Giardia duodenalis reduce enteric glial cells in the small intestine in mice.Parasitology research · 2018Article
- Assessing the Influence of Water Management and Rainfall Seasonality on Water Quality and Intestinal Parasitism in Rural Northeastern Brazil.Journal of tropical medicine · 2018Article
- The presence of Giardia intestinalis in donkeys, Equus asinus, in China.Parasites & vectors · 2017Article
- Molecular Epidemiology ofFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrent control policies for intestinal parasitosis focuses on soil-transmitted helminths, being ineffective against Giardia intestinalis, a highly prevalent protozoon that impacts children's nutritional status in developing countries. The objective of this study was to explore spatial and molecular epidemiology of Giardia intestinalis in children of Amerindian descent in the Brazilian Amazon. METHODOLOGY/PRINCIPAL
findingsA cross sectional survey was performed in the Brazilian Amazon with 433 children aged 1 to 14 years. Fecal samples were processed through parasitological techniques and molecular characterization. Prevalence of G. intestinalis infection was 16.9% (73/433), reaching 22.2% (35/158) among children aged 2-5 years, and a wide distribution throughout the city with some hot spots. Positivity-rate was similar among children living in distinct socioeconomic strata (48/280 [17.1%] and 19/116 [16.4%] below and above the poverty line, respectively). Sequencing of the β-giardin gene revealed 52.2% (n = 12) of assemblage A and 47.8% (n = 11) of assemblage B with high haplotype diversity for the latter. The isolates clustered into two well-supported G. intestinalis clades. A total of 38 haplotypes were obtained, with the following subassemblages distribution: 5.3% (n = 2) AII, 26.3% (n = 10) AIII, 7.9% (n = 3) BIII, and 60.5% (n = 23) new B genotypes not previously described. CONCLUSIONS/SIGNIFICANCE: Giardia intestinalis infection presents a high prevalence rate among Amerindian descended children living in Santa Isabel do Rio Negro/Amazon. The wide distribution observed in a small city suggests the presence of multiple sources of infection, which could be related to environmental contamination with feces, possibly of human and animal origin, highlighting the need of improving sanitation, safe water supply and access to diagnosis and adequate treatment of infections.
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