ArticleJournal of psychiatric research2016
Suicide attempters with Borderline Personality Disorder show differential orbitofrontal and parietal recruitment when reflecting on aversive memories.
Article in Journal of psychiatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Brain functional changes of suicidal ideation and behaviours: a meta-analysis of task-based fMRI studies.Translational psychiatry · 2026Pooled it
- Neural Correlates Involved in Behavioral Metrics of Emotion Regulation and Suicidal Thoughts and Behaviors.Archives of suicide research : official journal of the International Academy for Suicide ResearchPooled it
- Comparing the neural bases of self- and social-reappraisal.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Neural Markers of Emotion Reactivity and Regulation Before and After a Targeted Social Rejection: Differences Among Girls With and Without Suicidal Ideation and Behavior Histories.Biological psychiatry · 2024Article
- The Role of Emotion Dysregulation in Understanding Suicide Risk: A Systematic Review of the Literature.Healthcare (Basel, Switzerland) · 2024Review
- Reduced suicidality after electroconvulsive therapy is linked to increased frontal brain activity in depressed patients: a resting-state fMRI study.Frontiers in psychiatry · 2023Article
- A Brain-Centric Model of Suicidal Behavior.The American journal of psychiatry · 2020Article
- Brain structure and symptom dimensions in borderline personality disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies.Molecular psychiatry · 2020Review
- Source-based morphometry reveals gray matter differences related to suicidal behavior in criminal offenders.Brain imaging and behavior · 2020Article
- Decreased Connection Between Reward Systems and Paralimbic Cortex in Depressive Patients.Frontiers in neuroscience · 2018Article
- Examining Brain Structures Associated With Emotional Intelligence and the Mediated Effect on Trait Creativity in Young Adults.Frontiers in psychology · 2018Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
Abstract
Suicidal behavior and difficulty regulating emotions are hallmarks of Borderline Personality Disorder (BPD). This study examined neural links between emotion regulation and suicide risk in BPD. 60 individuals with BPD (all female, mean age = 28.9 years), 46 of whom had attempted suicide, completed a fMRI task involving recalling aversive personal memories. Distance trials assessed the ability to regulate emotion by recalling memories from a third-person, objective viewpoint. Immerse trials assessed emotional reactivity and involved recalling memories from a first-person perspective. Behaviorally, both groups reported less negative affect on Distance as compared to Immerse trials. Neurally, two sets of findings were obtained. The first reflected differences between attempters and non-attempters. When immersing and distancing, attempters showed elevated recruitment of lateral orbitofrontal cortex, a brain region implicated in using negative cues to guide behavior. When distancing, attempters showed diminished recruitment of the precuneus, a region implicated in memory recall and perspective taking. The second set of findings related to individual differences in regulation success - the degree to which individuals used distancing to reduce negative affect. Here, we observed that attempters who successfully regulated exhibited precuneus recruitment that was more similar to non-attempters. These data provide insight into mechanisms underlying suicide attempts in BPD. Future work may examine if these findings generalize to other diagnoses and also whether prior findings in BPD differ across attempters and non-attempters.
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Registered trials
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