ArticleBMC nephrology2016
Functional impairment is associated with an increased risk of mortality in patients on chronic hemodialysis.
Article in BMC nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07033611 (Effects of Creatine Supplementation in Sarcopenic and Non-sarcopenic Patients on Chronic Hemodialysis), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Creatine Supplementation in Sarcopenic and Non-sarcopenic Patients on Chronic Hemodialysis
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Risk factors for mortality in elderly haemodialysis patients: a systematic review and meta-analysis.BMC nephrology · 2020Pooled it
- Oral creatine in hemodialysis patients increases physical functional capacity and muscle mass, an open label study.PloS one · 2025Trial
- Can preconception hematologic and biochemical parameters predict the subsequent pregnancy loss in patients with recurrent pregnancy loss?BMC pregnancy and childbirth · 2025Article
- Combined evaluation of geriatric nutritional risk index and modified creatinine index for predicting functional dependence in patients on Hemodialysis.BMC nephrology · 2025Article
- Frailty and dialysis initiation in the super-elderly.Clinical and experimental nephrology · 2024Article
- Patient-focused outcomes after initiation of dialysis for ESRD: mortality, hospitalization and functional impairment.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Observational
- A Simple Exercise Program for Patients With End-Stage Kidney Disease to Improve Strength and Quality of Life: Clinical Research Protocol.Canadian journal of kidney health and disease · 2023Article
- Decreased Physical and Daily Living Activities in Patients with Peripheral Arterial Disease on Hemodialysis.Journal of clinical medicine · 2022Article
- Activity of daily life dependency predicts the risk of mortality in patients with COVID-19 undergoing hemodialysis: a retrospective analysis of a single center with nosocomial outbreak.Renal replacement therapy · 2022Article
- Unveiling the Burden of Interactions Among Clinical Risk Factors for 1-Year Mortality in Hospitalized Older Patients.Frontiers in medicine · 2021Article
- Functional independence, access to kidney transplantation and waitlist mortality.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Article
- Main Risk Factors Related to Activities of Daily Living in Non-Dialysis Patients with Chronic Kidney Disease Stage 3-5: A Case-Control Study.Clinical interventions in aging · 2020Article
- Effects of Hemodiafiltration versus Conventional Hemodialysis in Children with ESKD: The HDF, Heart and Height Study.Journal of the American Society of Nephrology : JASN · 2019Observational
- Correlation Between Depressive Symptoms And Quality Of Life, And Associated Factors For Depressive Symptoms Among Rural Elderly In Anhui, China.Clinical interventions in aging · 2019Article
- A holistic approach to factors affecting depression in haemodialysis patients.International urology and nephrology · 2018Review
- Functional impairment and risk of mortality in patients on chronic hemodialysis: results of the Lazio Dialysis Registry.Journal of nephrology · 2018Article
- Development and validation of a prediction model for loss of physical function in elderly hemodialysis patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Observational
- Linking Neighborhood Context and Health in Community-Dwelling Older Adults in the Medicare Advantage Program.Journal of the American Geriatrics Society · 2018Article
- Associations of sleep disturbance with physical function and cognition in older adults with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Article
- 1-year course of fatigue in patients on chronic hemodialysis.International urology and nephrology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFunctional impairment is associated with adverse outcomes in older people, as well as in patients on chronic hemodialysis. The aim of the present study was to determine the characteristics associated with functional impairment in chronic hemodialysis, and to evaluate if functional impairment represents a risk factor for reduced survival in chronic hemodialysis.
methodsAll 132 chronic hemodialysis referring to the Hemodialysis Service of the Catholic University, Rome, Italy between November 2007 and May 2015 were included. All patients underwent comprehensive geriatric assessment; functional ability was estimated using two questionnaires exploring independency in bathing, dressing, toileting, transferring, continence, feeding (ADLs), and independency in using the telephone, shopping, food preparation, housekeeping, laundering, traveling, taking medications, and handling finances (IADLs). Functional impairment was diagnosed in presence of dependence in one or more ADLs/IADLs. Mood was assessed using the 30-item Geriatric Depression Scale. Logistic regression was used to evaluate factors associated with functional impairment. The association between functional impairment and survival was assessed by Cox regression.
resultsADLs impairment was present in 34 (26 %) participants, while IADLs impairment was detected in 64 (48 %) subjects. After a follow up of 90 months, 55 (42 %) patients died. In logistic regression, depressive symptoms were associated with ADLs and IADLs impairment (OR 1.12; 95 % CI = 1.02-1.23; OR 1.16; 95 % CI = 1.02-1.33; respectively). In Cox regression, ADLs impairment was associated with mortality (HR 2.47; 95 % CI-1.07-5.67) while IADLs impairment was not associated with reduced survival (HR .80; 95 % CI-.36-1.76).
conclusionsFunctional impairment is associated with depressive symptoms; also, impairment in the ADLs represents a risk factor of reduced survival in chronic hemodialysis. These associations and their potential implication should be assessed in dedicated studies.
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