ArticlePloS one2016
Expression Patterns of Three UGT Genes in Different Chemotype Safflower Lines and under MeJA Stimulus Revealed Their Potential Role in Flavonoid Biosynthesis.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 27 citations in OpenAlex.
- Research Progress of Genomics Applications in Secondary Metabolites of Medicinal Plants: A Case Study in Safflower.International journal of molecular sciences · 2025Review
- Genome-wide screen and multi-omics analysis revealHorticulture research · 2024Article
- Characterization of UGT71, a major glycosyltransferase family for triterpenoids, flavonoids and phytohormones-biosynthetic in plants.Forestry research · 2024Review
- Inhibition of Uridine 5'-diphospho-glucuronosyltransferases A10 and B7 by vitamins: insights from in silico and in vitro studies.In silico pharmacology · 2024Article
- A Muti-Substrate FlavonolMolecules (Basel, Switzerland) · 2023Article
- Genome-Wide Identification and Characterization of thePlants (Basel, Switzerland) · 2023Article
- Identification and Characterization of CtUGT3 as the Key Player of Astragalin Biosynthesis inJournal of agricultural and food chemistry · 2023Article
- Phylogenetic relationship and sequence diversity of candidate genes involved in anthocyanin biosynthesis pathway inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- Integrated metabolomics and transcriptome analysis on flavonoid biosynthesis in safflower (Carthamus tinctorius L.) under MeJA treatment.BMC plant biology · 2020Article
- Transcriptome Sequencing and Chemical Analysis Reveal the Formation Mechanism of White Florets inPlants (Basel, Switzerland) · 2020Article
- Phaeophyceaean (Brown Algal) Extracts Activate Plant Defense Systems inFrontiers in plant science · 2020Article
- Molecular cloning and functional characterization of chalcone isomerase from Carthamus tinctorius.AMB Express · 2019Article
- Full-length transcriptome sequences and the identification of putative genes for flavonoid biosynthesis in safflower.BMC genomics · 2018Article
- Molecular differentiation of five Cinnamomum camphora chemotypes using desorption atmospheric pressure chemical ionization mass spectrometry of raw leaves.Scientific reports · 2017Article
- Overexpression ofFrontiers in plant science · 2017Article
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Safflower (Carthamus tinctorius L.) has received a significant amount of attention as a medicinal plant in China. Flavonoids are the dominant active medical compounds. UDP-glycosyltransferase plays an essential role in the biosynthesis and storage of flavonoids in safflower. In this study, 45 UGT unigenes were screened from our transcriptomic database of safflower. Among them, 27 UGT unigenes were predicted to own a complete open reading frame with various pI and Mw. The phylogenetic tree showed that CtUGT3 and CtUGT16 were classified under the UGT71 subfamily involved in metabolite process, whereas CtUGT25 has high identities with PoUGT both catalyzing the glycosylation of flavonoids and belonging to the UGT90 subfamily. cDNA microarray exhibited that the three UGT genes displayed temporal difference in two chemotype safflower lines. To functionally characterize UGT in safflower, CtUGT3, CtUGT16 and CtUGT25 were cloned and analyzed. Subcellular localization suggested that the three UGTs might be located in the cell cytoplasm and chloroplast. The expression pattern showed that the three UGTs were all suppressed in two lines responsive to methyl jasmonate induction. The co-expression relation of expression pattern and metabolite accumulation demonstrated that CtUGT3 and CtUGT25 were positively related to kaempferol-3-O-β-D-glucoside and CtUGT16 was positively related to quercetin-3-O-β-D-glucoside in yellow line, whereas CtUGT3 and CtUGT25 were positively related to quercetin-3-O-β-D-glucoside in white line. This study indicates that the three CtUGTs play a significant and multiple role in flavonoids biosynthesis with presenting different functional characterization in two safflower lines.
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