Evidence map›Paper›PMID 27391774›Full record

Trial reportBMC nephrology2016

Design and methods of CYCLE-HD: improving cardiovascular health in patients with end stage renal disease using a structured programme of exercise: a randomised control trial.

M P M Graham-Brown, D S March, D R Churchward, H M L Young, M Dungey, S Lloyd, N J Brunskill, A C Smith, G P McCann, J O Burton

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Exercise training for adults undergoing maintenance dialysis.The Cochrane database of systematic reviews · 2022
    Pooled it
  2. Interventions for itch in people with advanced chronic kidney disease.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Review
  10. Article
  11. Article
  12. Chronic kidney disease, physical activity and cognitive function in older adults-results from the National Health and Nutrition Examination Survey (2011-2014).Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022
    Article
  13. Global Policy Barriers and Enablers to Exercise and Physical Activity in Kidney Care.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2022
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

M P M Graham-BrownJohn Walls Renal Unit, University Hospitals Leicester NHS Trust, Leicester, UK. mpmgb1@le.ac.uk.
D S MarchJohn Walls Renal Unit, University Hospitals Leicester NHS Trust, Leicester, UK.
D R ChurchwardJohn Walls Renal Unit, University Hospitals Leicester NHS Trust, Leicester, UK.
H M L YoungJohn Walls Renal Unit, University Hospitals Leicester NHS Trust, Leicester, UK.
M DungeyJohn Walls Renal Unit, University Hospitals Leicester NHS Trust, Leicester, UK.
S LloydRobertson Centre for Biostatistics University of Glasgow, Glasgow, UK.
N J BrunskillJohn Walls Renal Unit, University Hospitals Leicester NHS Trust, Leicester, UK.
A C SmithJohn Walls Renal Unit, University Hospitals Leicester NHS Trust, Leicester, UK.
G P McCannJohn Walls Renal Unit, University Hospitals Leicester NHS Trust, Leicester, UK.
J O BurtonJohn Walls Renal Unit, University Hospitals Leicester NHS Trust, Leicester, UK.
University Hospitals of Leicester NHS Trust · GBUniversity of Leicester · GBUniversity of Glasgow · GB

Funding

Department of Health CDF-2014-07-045Department of Health CS-2013-13-014Department of Health DRF-2016-09-015
6 · The paper itself

Abstract

backgroundThere is emerging evidence that exercise training could positively impact several of the cardiovascular risk factors associated with sudden cardiac death amongst patients on haemodialysis. The primary aim of this study is to evaluate the effect of an intradialytic exercise programme on left ventricular mass. METHOD AND

designProspective, randomised cluster open-label blinded endpoint clinical trial in 130 patients with end stage renal disease on haemodialysis. Patients will be randomised 1:1 to either 1) minimum of 30 min continuous cycling thrice weekly during dialysis or 2) standard care. The primary outcome is change in left ventricular mass at 6 months, assessed by cardiac MRI (CMR). In order to detect a difference in LV mass of 15 g between groups at 80 % power, a sample size of 65 patients per group is required. Secondary outcome measures include abnormalities of cardiac rhythm, left ventricular volumes and ejection fraction, physical function measures, anthropometric measures, quality of life and markers of inflammation, with interim assessment for some measures at 3 months. DISCUSSION: This study will test the hypothesis that an intradialytic programme of exercise leads to a regression in left ventricular mass, an important non-traditional cardiovascular risk factor in end stage renal disease. For the first time this will be assessed using CMR. We will also evaluate the efficacy, feasibility and safety of an intradialytic exercise programme using a number of secondary end-points. We anticipate that a positive outcome will lead to both an increased patient uptake into established intradialytic programmes and the development of new programmes nationally and internationally. TRIAL REGISTRATION NUMBER: ISRCTN11299707 (registration date 5(th) March 2015).

Indexed as

Cardiovascular Physiological PhenomenaExercise TherapyBody SizeCardiac VolumeDeath, Sudden, CardiacExerciseHumansHypertrophy, Left VentricularInflammationKidney Failure, ChronicMagnetic Resonance ImagingQuality of LifeRenal DialysisResearch DesignStroke VolumeCardiovascular diseaseHaemodialysisIntra-dialytic cyclingIntra-dialytic exerciseSudden cardiac death

Identifiers

PMID27391774
PMCPMC4938939
OpenAlexW2470681082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.