ArticleAlzheimer's research & therapy2015
Elevated cerebrovascular resistance index is associated with cognitive dysfunction in the very-old.
Article in Alzheimer's research & therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Evaluation of the correlation between cerebral hemodynamics and blood pressure by comparative analysis of variation in cerebral blood flow in hypertensive versus normotensive individuals: A systematic review and meta-analysis.Biomolecules & biomedicine · 2024Pooled it
- Interaction between systemic arterial reservoir behavior and cerebrovascular vasoreactivity during acute controlled hypocapnia.Scientific reports · 2026Article
- Mild cognitive impairment cases affect the predictive power of Alzheimer's disease diagnostic models using routine clinical variables.npj aging · 2026Article
- Cerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriers.GeroScience · 2025Article
- Contrast-Enhanced Ultrasound Imaging Detects Anatomical and Functional Changes in Rat Cervical Spine Microvasculature With Normal Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Contrast-enhanced ultrasound imaging detects anatomical and functional changes in rat cervical spine microvasculature with normal aging.bioRxiv : the preprint server for biology · 2024Article
- Cerebrovascular adaptations to habitual resistance exercise with aging.American journal of physiology. Heart and circulatory physiology · 2024Review
- Self-reported fraud victimization and objectively measured blood pressure: Sex differences in post-fraud cardiovascular health.Journal of the American Geriatrics Society · 2022Article
- Cortical Anoxic Spreading Depolarization During Cardiac Arrest is Associated with Remote Effects on Peripheral Blood Pressure and Postresuscitation Neurological Outcome.Neurocritical care · 2022Article
- Potential Mechanisms Underlying Resistance to Dementia in Non-Demented Individuals with Alzheimer's Disease Neuropathology.Journal of Alzheimer's disease : JAD · 2022Review
- Arterial stiffening acts synergistically with APOE genotype and AD biomarker status to influence memory in older adults without dementia.Alzheimer's research & therapy · 2021Article
- Associations of decision making abilities with blood pressure values in older adults.Journal of hypertension · 2020Article
- APOE genotype modifies the association between central arterial stiffening and cognition in older adults.Neurobiology of aging · 2018Article
- Detrimental effect of systemic vascular risk factors on brain hemodynamic function assessed with MRI.The neuroradiology journal · 2018Article
- Brain imaging of neurovascular dysfunction in Alzheimer's disease.Acta neuropathologica · 2016Review
- The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer's Disease.Cellular and molecular neurobiology · 2016Review
- Pulse pressure in relation to tau-mediated neurodegeneration, cerebral amyloidosis, and progression to dementia in very old adults.JAMA neurology · 2015Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
introductionAge-related vascular changes, including blood pressure elevation and cerebral blood flow (CBF) reduction, are associated with cognitive decline and Alzheimer's disease (AD). Evidence suggests that the relationship between blood pressure and dementia risk varies between younger and older samples within the elderly population.
methodsWe examined the relationship between mean arterial pressure (MAP), CBF, and cognition in young-old (60 to 75 years of age) versus very-old (80+ years of age) adults. Fifty-eight non-demented older adults completed an arterial spin labeling MRI scan, and an index of cerebrovascular resistance (CVRi) was estimated for each participant by calculating the ratio of MAP and CBF.
resultsResults demonstrated a similar negative relationship between MAP and CBF across both age groups. However, very-old participants exhibited elevated CVRi and reduced CBF compared to young-old participants in regions implicated in AD and cerebral small vessel disease. Furthermore, significant age by CVRi interactions revealed that elevated CVRi in the thalamus was inversely related to verbal fluency performance in the very-old group.
conclusionsFindings support CVRi as a potential vascular biomarker and suggest that regionally-specific vascular changes may contribute to cognitive decline, particularly in the very-old.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.