ArticleBMC psychiatry2016
Exposure to environmental factors increases connectivity between symptom domains in the psychopathology network.
Article in BMC psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Genetic Susceptibility to the Environment Moderates the Impact of Childhood Experiences on Psychotic, Depressive, and Anxiety Dimensions.Schizophrenia bulletin · 2025Article
- Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and Affective Reactivity in Daily Life.Schizophrenia bulletin · 2025Article
- Network analysis in depressed adolescents with suicidal ideation: the role of depression, anxiety, and childhood abuse.Frontiers in psychiatry · 2025Article
- The Associations of Exposome Score with Various Domains of Psychopathology: A Network Analysis in a Non-Clinical Sample.Brain sciences · 2024Article
- Childhood maltreatment mediates the effect of the genetic background on psychosis risk in young adults.Translational psychiatry · 2022Article
- A network approach to relationships between cannabis use characteristics and psychopathology in the general population.Scientific reports · 2022Article
- The Exposome Paradigm to Understand the Environmental Origins of Mental Disorders.Alpha psychiatry · 2021Review
- The network structure of schizotypy in the general population.European archives of psychiatry and clinical neuroscience · 2021Article
- Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness.Acta psychiatrica Scandinavica · 2020Article
- Evidence for interaction between genetic liability and childhood trauma in the development of psychotic symptoms.Social psychiatry and psychiatric epidemiology · 2019Article
- Evidence That Environmental and Familial Risks for Psychosis Additively Impact a Multidimensional Subthreshold Psychosis Syndrome.Schizophrenia bulletin · 2018Article
- Network Approach to Understanding Emotion Dynamics in Relation to Childhood Trauma and Genetic Liability to Psychopathology: Replication of a Prospective Experience Sampling Analysis.Frontiers in psychology · 2017Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe investigated to what degree environmental exposure (childhood trauma, urbanicity, cannabis use, and discrimination) impacts symptom connectivity using both continuous and categorical measures of psychopathology.
methodsOutcomes were continuous symptom dimensions of self-reported psychopathology using the Self-report Symptom Checklist-90-R in 3021 participants from The Early Developmental Stages of the Psychopathology (EDSP) study and binary DSM-III-R categories of mental disorders and a binary measure of psychotic symptoms in 7076 participants from The Netherlands Mental Health Survey and Incidence Study (NEMESIS-1). For each symptom dimension in the EDSP and mental disorder in the NEMESIS-1 as the dependent variable, regression analyses were carried out including each of the remaining symptom dimensions/mental disorders and its interaction with cumulative environmental risk load (the sum score of environmental exposures) as independent variables.
resultsAll symptom dimensions in the EDSP and related diagnostic categories in the NEMESIS-1 were strongly associated with each other, and environmental exposures increased the degree of symptom connectivity in the networks in both cohorts.
conclusionsOur findings showing strong connectivity across symptom dimensions and related binary diagnostic constructs in two independent population cohorts provide further evidence for the conceptualization of psychopathology as a contextually sensitive network of mutually interacting symptoms.
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